Ubiquitin-like protein required for autophagy. Conjugated to ATG3 and ATG5. Ubiquitous. Belongs to the ATG12 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Molecular Function: APG8 conjugating enzyme activity; protein binding
Biological Process: autophagic vacuole formation; C-terminal protein lipidation; innate immune response; macroautophagy; macromitophagy; mitochondrion degradation; negative regulation of interferon type I production
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.