Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms. Belongs to the peptidase C19 family. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.2.-; EC 3.4.19.-; Protease; Ubiquitin-specific protease