Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
USP18 (human)

Overview
USP18 Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms. Belongs to the peptidase C19 family. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.19.-; EC 3.1.2.-; Ubiquitin-specific protease; Protease
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component: cytosol; nucleus
Molecular Function: ISG15-specific protease activity; protein binding; ubiquitin-specific protease activity
Biological Process: protein deubiquitination; ubiquitin-dependent protein catabolic process
Reference #:  Q9UMW8 (UniProtKB)
Alt. Names/Synonyms: 43 kDa ISG15-specific protease; hUBP43; ISG15-specific-processing protease; ISG43; ubiquitin specific peptidase 18; ubiquitin specific protease 18; Ubl carboxyl-terminal hydrolase 18; Ubl thioesterase 18; UBP18; UBP43; USP18
Gene Symbols: USP18
Molecular weight: 43,011 Da
Basal Isoelectric point: 8.05  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

USP18

Protein Structure Not Found.


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB


Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y125‑p VRPLELAyCLQKCNV
  mouse

 
Q122 VLPTELVQCLQKYNV
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.