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Protein Page:
AurC (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AurC a member of the AUR family of kinases. May play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. Localized to centrosome from anaphase to cytokinesis. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Other; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Other group; AUR family
Chromosomal Location of Human Ortholog: 19q13.43
Cellular Component: condensed chromosome; condensed nuclear chromosome, pericentric region; midbody; spindle; spindle microtubule; spindle midzone; spindle pole centrosome
Molecular Function: histone serine kinase activity; protein kinase activity; protein serine/threonine/tyrosine kinase activity
Biological Process: attachment of spindle microtubules to kinetochore; histone modification; positive regulation of cytokinesis; protein amino acid phosphorylation; spindle midzone assembly involved in mitosis
Disease: Spermatogenic Failure 5
Reference #:  Q9UQB9 (UniProtKB)
Alt. Names/Synonyms: AIE2; AIK3; ARK-3; ARK3; AurC; AURKC; Aurora C; Aurora kinase C; aurora-C; Aurora-related kinase 3; Aurora/IPL1-related kinase 3; Aurora/IPL1/Eg2 protein 2; serine/threonine kinase 13 (aurora/IPL1-like); Serine/threonine-protein kinase 13; Serine/threonine-protein kinase aurora-C; STK13
Gene Symbols: AURKC
Molecular weight: 35,591 Da
Basal Isoelectric point: 8.96  Predict pI for various phosphorylation states
Select Structure to View Below

AurC

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S32‑p QTAQQPSsPAMRRLT
0 1 S77‑p ALKVLFKsQIEKEGL
0 1 K197‑ac HTPSLRRktMCGtLD
5 89 T198‑p TPSLRRktMCGtLDY
3 20 T202‑p RRktMCGtLDYLPPE
0 1 S271‑p LGARDLIsRLLRYQP
2914 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb
2995 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Biotinylated)
8525 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
13464 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb  (Alexa Fluor(R) 555 Conjugate)
  AurC iso2  
- gap
S43 ALKVLFKSQIEKEGL
K163 HTPSLRRKtMCGTLD
T164‑p TPSLRRKtMCGTLDY
T168 RRKtMCGTLDYLPPE
S237 LGARDLISRLLRYQP
  mouse

 
- gap
S50 ALKVLFKSEIEKEGL
K170 HTPSLRRKtMCGtLD
T171‑p TPSLRRKtMCGtLDY
T175‑p RRKtMCGtLDYLPPE
S244 AGAQDLISKLLRYHP
2914 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb
2995 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Biotinylated)
8525 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
13464 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb  (Alexa Fluor(R) 555 Conjugate)
  rat

 
P31 FHFSCGIPLLGKHFT
S76 ALKVLFKSEIGKEGL
K196 HTPSLRRKTMCGTLD
T197 TPSLRRKTMCGTLDY
T201 RRKTMCGTLDYLPPE
S270 AGAQDLISKLLRHHP
2914 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb
2995 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Biotinylated)
8525 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
13464 : Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) XP(R) Rabbit mAb  (Alexa Fluor(R) 555 Conjugate)
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