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Protein Page:
Lamin B1 (human)

Overview
Lamin B1 nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Nuclear lamins are cleaved by caspases during apoptosis. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 5q23.2
Cellular Component: membrane; nuclear envelope; nuclear membrane; nucleoplasm
Disease: Leukodystrophy, Demyelinating, Adult-onset, Autosomal Dominant
Reference #:  P20700 (UniProtKB)
Alt. Names/Synonyms: ADLD; lamin B1; Lamin-B1; LMN; LMN2; LMNB; LMNB1; MGC111419
Gene Symbols: LMNB1
Molecular weight: 66,408 Da
Basal Isoelectric point: 5.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Lamin B1

Protein Structure Not Found.
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