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Protein Page:
PSA (human)

Overview
PSA Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. Forms heterodimer with SERPINA5. Inhibited by SERPINA5. Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders. Belongs to the peptidase S1 family. Kallikrein subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.21.77; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19q13.41
Cellular Component: extracellular region; extracellular space; nucleus; protein complex
Molecular Function: endopeptidase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; protein binding; serine-type endopeptidase activity; serine-type peptidase activity
Biological Process: antibacterial peptide production; cellular protein metabolic process; proteolysis
Reference #:  P07288 (UniProtKB)
Alt. Names/Synonyms: APS; Gamma-seminoprotein; hK3; Kallikrein-3; kallikrein-related peptidase 3; KLK2A1; KLK3; P-30 antigen; prostate specific antigen; Prostate-specific antigen; PSA; Semenogelase; Seminin
Gene Symbols: KLK3
Molecular weight: 28,741 Da
Basal Isoelectric point: 7.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PSA

Protein Structure Not Found.
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