Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
HLAA iso80 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HLAA iso80 Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family. Note: This description may include information from UniProtKB.
Protein type: Immunoglobulin superfamily; Membrane protein, integral
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: cell surface; early endosome membrane; endoplasmic reticulum; Golgi apparatus; Golgi membrane; MHC class I protein complex; phagocytic vesicle membrane; plasma membrane
Molecular Function: beta-2-microglobulin binding; peptide antigen binding; protein binding
Biological Process: antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; antigen processing and presentation of peptide antigen via MHC class I; regulation of immune response
Reference #:  Q09160 (UniProtKB)
Alt. Names/Synonyms: HLA-A; HLAA
Gene Symbols: HLA-A
Molecular weight: 40,792 Da
Basal Isoelectric point: 5.9  Predict pI for various phosphorylation states
Select Structure to View Below

HLAA iso80

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


cBioPortal  |  Wikipedia  |  Scansite  |  Pfam  |  GeneCards  |  UniProtKB  |  Entrez-Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T8‑p MAVMAPRtLVLLLSG
0 1 S35 SMRYFFTSVSRPGRG
0 1 Y51‑p PRFIAVGyVDDTQFV
0 1 R68 DSDAASQRMEPRAPW
0 1 Y83‑p IEQEGPEyWDGETRK
0 5 K92 DGETRKVKAHSQTHR
0 1 Y137‑p DWRFLRGyHQyAYDG
0 1 Y140‑p FLRGyHQyAYDGKDY
0 1 Y147 yAYDGKDYIALkEDL
0 2 K151‑ub GKDYIALkEDLRSWT
0 2 T167 ADMAAQTTKHKWEAA
0 3 K170 AAQTTKHKWEAAHVA
0 49 K200‑ub RRYLENGkETLQRTD
0 1 K210 LQRTDAPKTHMTHHA
0 1 S219‑p HMTHHAVsDHEATLR
0 5 K267‑ub AGDGTFQkWAAVVVP
0 1 S275 WAAVVVPSGQEQRYT
0 1 Q277 AVVVPSGQEQRYTCH
0 7 K292‑ub VQHEGLPkPLTLRWE
1 1 S337‑p VMWRRKSsDRkGGsy
0 50 K340‑ub RRKSsDRkGGsysQA
1 7 S343‑p SsDRkGGsysQAAss
1 24 Y344‑p sDRkGGsysQAAssD
0 10 S345‑p DRkGGsysQAAssDs
0 3 S349‑p GsysQAAssDsAQGs
0 4 S350‑p sysQAAssDsAQGsD
0 19 S352‑p sQAAssDsAQGsDVs
0 21 S356‑p ssDsAQGsDVsLtAC
1 21 S359‑p sAQGsDVsLtACkV_
0 8 T361‑p QGsDVsLtACkV___
0 38 K364‑ub DVsLtACkV______
  HLAA iso3  
T8 MAVMAPRTLLLLLSG
S35 SMRYFFTSVSRPGRG
Y51 PRFIAVGYVDDTQFV
R68 DSDAASQRMEPRAPW
Y83 IEQEGPEYWDQETRN
K92‑ub DQETRNVkAQSQTDR
Y137 DGRFLRGYRQDAYDG
D140 FLRGYRQDAYDGKDy
Y147‑p DAYDGKDyIALNEDL
N151 GKDyIALNEDLRSWT
T167‑p ADMAAQItKRKWEAA
K170 AAQItKRKWEAAHEA
K200‑ub RRYLENGkETLQRTD
K210 LQRTDPPKTHMTHHP
S219‑p HMTHHPIsDHEATLR
K267‑ub AGDGTFQkWAAVVVP
S275‑p WAAVVVPsGEEQRYT
E277 AVVVPsGEEQRYTCH
K292 VQHEGLPKPLTLRWE
S337 VMWRRKSSDRkGGsy
K340‑ub RRKSSDRkGGsytQA
S343‑p SSDRkGGsytQAAss
Y344‑p SDRkGGsytQAAssD
T345‑p DRkGGsytQAAssDs
S349‑p GsytQAAssDsAQGs
S350‑p sytQAAssDsAQGsD
S352‑p tQAAssDsAQGsDVs
S356‑p ssDsAQGsDVsLtAC
S359‑p sAQGsDVsLtACkV_
T361‑p QGsDVsLtACkV___
K364‑ub DVsLtACkV______
  HLAA iso23  
T8 MAVMAPRTLVLLLSG
S35 SMRYFSTSVSRPGRG
Y51 PRFIAVGYVDDTQFV
R68 DSDAASQRMEPRAPW
Y83‑p IEQEGPEyWDEETGK
K92 DEETGKVKAHSQTDR
Y137 DGRFLRGYHQYAYDG
Y140 FLRGYHQYAYDGKDY
Y147 YAYDGKDYIALKEDL
K151 GKDYIALKEDLRSWT
T167 ADMAAQITQRKWEAA
K170 AAQITQRKWEAARVA
K200 RRYLENGKETLQRTD
K210 LQRTDPPKTHMTHHP
S219‑p HMTHHPIsDHEATLR
K267 AGDGTFQKWAAVVVP
S275‑p WAAVVVPsGEEQRYT
E277 AVVVPsGEEQRYTCH
K292 VQHEGLPKPLTLRWE
S337 VMWRRNSSDRKGGSY
K340 RRNSSDRKGGSYSQA
S343 SSDRKGGSYSQAASS
Y344 SDRKGGSYSQAASSD
S345 DRKGGSYSQAASSDS
S349 GSYSQAASSDSAQGS
S350 SYSQAASSDSAQGSD
S352 SQAASSDSAQGSDVS
S356 SSDSAQGSDVSLTAC
S359 SAQGSDVSLTACKV_
T361 QGSDVSLTACKV___
K364 DVSLTACKV______
  HLAA iso24  
T8 MAVMAPRTLVLLLSG
S35 SMRYFSTSVSRPGRG
Y51 PRFIAVGYVDDTQFV
R68 DSDAASQRMEPRAPW
Y83‑p IEQEGPEyWDEETGK
K92 DEETGKVKAHSQTDR
Y137 DGRFLRGYHQYAYDG
Y140 FLRGYHQYAYDGKDY
Y147 YAYDGKDYIALKEDL
K151 GKDYIALKEDLRSWT
T167‑p ADMAAQItKRKWEAA
K170 AAQItKRKWEAAHVA
K200‑ub RRYLENGkETLQRTD
K210 LQRTDPPKTHMTHHP
S219‑p HMTHHPIsDHEATLR
K267‑ub AGDGTFQkWAAVVVP
S275‑p WAAVVVPsGEEQRYT
E277 AVVVPsGEEQRYTCH
K292 VQHEGLPKPLTLRWE
S337 VMWRRNSSDRKGGSY
K340 RRNSSDRKGGSYSQA
S343 SSDRKGGSYSQAASS
Y344 SDRKGGSYSQAASSD
S345 DRKGGSYSQAASSDS
S349 GSYSQAASSDSAQGS
S350 SYSQAASSDSAQGSD
S352 SQAASSDSAQGSDVS
S356 SSDSAQGSDVSLTAC
S359 SAQGSDVSLTACKV_
T361 QGSDVSLTACKV___
K364 DVSLTACKV______
  HLAA iso25  
T8 MAVMAPRTLVLLLSG
S35 SMRYFYTSVSRPGRG
Y51 PRFIAVGYVDDTQFV
R68 DSDAASQRMEPRAPW
Y83‑p IEQEGPEyWDRNTRN
K92 DRNTRNVKAHSQTDR
Y137 DGRFLRGYQQDAYDG
D140 FLRGYQQDAYDGKDy
Y147‑p DAYDGKDyIALNEDL
N151 GKDyIALNEDLRSWT
T167‑p ADMAAQItQRkWETA
K170‑ub AAQItQRkWETAHEA
K200 RRYLENGKETLQRTD
K210 LQRTDAPKTHMTHHA
S219 HMTHHAVSDHEATLR
K267‑ub AGDGTFQkWASVVVP
S275 WASVVVPSGQEQRYT
Q277 SVVVPSGQEQRYTCH
K292 VQHEGLPKPLTLRWE
S337‑p VMWRRKSsDRkGGsy
K340‑ub RRKSsDRkGGsysQA
S343‑p SsDRkGGsysQAAss
Y344‑p sDRkGGsysQAAssD
S345‑p DRkGGsysQAAssDs
S349‑p GsysQAAssDsAQGs
S350‑p sysQAAssDsAQGsD
S352‑p sQAAssDsAQGsDMs
S356‑p ssDsAQGsDMsLtAC
S359‑p sAQGsDMsLtACkV_
T361‑p QGsDMsLtACkV___
K364‑ub DMsLtACkV______
  HLAA iso31  
T8 MAVMAPRTLLLLLLG
S35 SMRYFTTSVSRPGRG
Y51 PRFIAVGYVDDTQFV
R68 DSDAASQRMEPRAPW
Y83 IEQERPEYWDQETRN
K92‑ub DQETRNVkAHSQIDR
Y137 DGRFLRGYQQDAYDG
D140 FLRGYQQDAYDGKDy
Y147‑p DAYDGKDyIALNEDL
N151 GKDyIALNEDLRSWT
T167‑p ADMAAQItQRKWEAA
K170 AAQItQRKWEAARVA
K200 RRYLENGKETLQRTD
K210 LQRTDPPKTHMTHHA
S219 HMTHHAVSDHEATLR
K267‑ub AGDGTFQkWASVVVP
S275 WASVVVPSGQEQRYT
Q277 SVVVPSGQEQRYTCH
K292 VQHEGLPKPLTLRWE
S337‑p VRWRRKSsDRkGGsy
K340‑ub RRKSsDRkGGsysQA
S343‑p SsDRkGGsysQAAss
Y344‑p sDRkGGsysQAAssD
S345‑p DRkGGsysQAAssDs
S349‑p GsysQAAssDsAQGs
S350‑p sysQAAssDsAQGsD
S352‑p sQAAssDsAQGsDMs
S356‑p ssDsAQGsDMsLtAC
S359‑p sAQGsDMsLtACkV_
T361‑p QGsDMsLtACkV___
K364‑ub DMsLtACkV______
  HLAA iso36  
T8 MAVMAPRTLLLLLSG
S35 SMRYFFTSVSRPGRG
Y51 PRFIAVGYVDDTQFV
K68‑ub DSDAASQkMEPRAPW
Y83 IEQEGPEYWDQETRN
K92‑ub DQETRNMkAHSQTDR
Y137 DGRFLRGYRQDAYDG
D140 FLRGYRQDAYDGKDy
Y147‑p DAYDGKDyIALNEDL
N151 GKDyIALNEDLRSWT
T167‑p ADMAAQItKRkWEAV
K170‑ub AAQItKRkWEAVHAA
K200 RRYLENGKETLQRTD
K210 LQRTDPPKTHMTHHP
S219‑p HMTHHPIsDHEATLR
K267‑ub AGDGTFQkWAAVVVP
S275‑p WAAVVVPsGEEQRYT
E277 AVVVPsGEEQRYTCH
K292 VQHEGLPKPLTLRWE
S337 VMWRRKSSDRkGGsy
K340‑ub RRKSSDRkGGsytQA
S343‑p SSDRkGGsytQAAss
Y344‑p SDRkGGsytQAAssD
T345‑p DRkGGsytQAAssDs
S349‑p GsytQAAssDsAQGs
S350‑p sytQAAssDsAQGsD
S352‑p tQAAssDsAQGsDVs
S356‑p ssDsAQGsDVsLtAC
S359‑p sAQGsDVsLtACkV_
T361‑p QGsDVsLtACkV___
K364‑ub DVsLtACkV______
  HLAA iso80  
T8 MAVMPPRTLLLLLSG
S35 SMRYFFTSVSRPGRG
Y51 PRFIAVGYVDDSQFV
R68 DSDAASQRMEPRAPW
Y83 IEQEEPEYWDEETRN
K92 DEETRNVKAHSQTNR
Y137 DGRFLRGYRQDAYDG
D140 FLRGYRQDAYDGKDy
Y147‑p DAYDGKDyIALNEDL
N151 GKDyIALNEDLRSWT
T167‑p