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Protein Page:
TRB2 (human)

Overview
TRB2 Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; CAMK group; Trbl family
Chromosomal Location of Human Ortholog: 2p24.3
Cellular Component: cytoplasm; cytoskeleton; nucleus
Molecular Function: mitogen-activated protein kinase kinase binding; nucleotide binding; protein kinase activity; protein kinase inhibitor activity; transcription factor binding; ubiquitin protein ligase binding; ubiquitin-protein ligase regulator activity
Biological Process: negative regulation of fat cell differentiation; negative regulation of interleukin-10 biosynthetic process; negative regulation of protein kinase activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein amino acid phosphorylation; regulation of MAP kinase activity
Reference #:  Q92519 (UniProtKB)
Alt. Names/Synonyms: C5FW; FLJ57420; GS3955; TRB-2; TRB2; TRIB2; Tribbles homolog 2; tribbles homolog 2 (Drosophila)
Gene Symbols: TRIB2
Molecular weight: 38,801 Da
Basal Isoelectric point: 5.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TRB2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y14‑p TPITIARyGRSRNKT
1 0 S83‑p FRAVHLHsGEELVCK
0 1 S133‑p AYVFFERsyGDMHsF
0 1 Y134‑p YVFFERsyGDMHsFV
0 1 S139‑p RsyGDMHsFVRtCKK
0 1 T143‑p DMHsFVRtCKKLREE
0 1 Y218‑p DKHGCPAyVSPEILN
0 1 T298‑p REPSERLtsQEILDH
0 1 S299‑p EPSERLtsQEILDHP
  mouse

 
Y14 TPITIARYGRSRNKT
S83 FRAVHLHSGEELVCK
S133 AYVFFERSYGDMHSF
Y134 YVFFERSYGDMHSFV
S139 RSYGDMHSFVRTCKK
T143 DMHSFVRTCKKLREE
Y218 DKHGCPAYVSPEILN
T298 REPSERLTSQEILDH
S299 EPSERLTSQEILDHP
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