Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
PSME1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PSME1 Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. Heterodimer of PSME1 and PSME2, which forms a hexadimeric ring. PSME1 can form homoheptamers. By IFNG/IFN-gamma. Belongs to the PA28 family. Note: This description may include information from UniProtKB.
Protein type: Proteasome complex
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: cytoplasm; cytosol; nucleoplasm; proteasome activator complex; proteasome complex
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; MAPKKK cascade; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of amino acid metabolic process; regulation of mRNA stability; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway
Reference #:  Q06323 (UniProtKB)
Alt. Names/Synonyms: 11S regulator complex alpha subunit; 11S regulator complex subunit alpha; 29-kD MCP activator subunit; Activator of multicatalytic protease subunit 1; IFI5111; IGUP I-5111; Interferon gamma up-regulated I-5111 protein; interferon-gamma IEF SSP 5111; interferon-gamma-inducible protein 5111; MGC8628; PA28a; PA28alpha; proteasome (prosome, macropain) activator subunit 1 (PA28 alpha); Proteasome activator 28 subunit alpha; Proteasome activator complex subunit 1; proteasome activator subunit-1; PSME1; REG-alpha; REGalpha
Gene Symbols: PSME1
Molecular weight: 28,723 Da
Basal Isoelectric point: 5.78  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PSME1

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K13‑ac VQPEAQAkVDVFRED
0 2 K13‑ub VQPEAQAkVDVFRED
0 1 T23‑p VFREDLCtktENLLG
0 3 K24‑ub FREDLCtktENLLGS
0 1 T25‑p REDLCtktENLLGSY
0 5 K35‑ac LLGSYFPkkISELDA
0 5 K35‑ub LLGSYFPkkISELDA
0 1 K35‑sc LLGSYFPkkISELDA
0 2 K36‑ub LGSYFPkkISELDAF
0 1 K45 SELDAFLKEPALNEA
0 1 S55‑p ALNEANLsNLKAPLD
0 1 K70 IPVPDPVKEKEKEER
0 1 K90‑ac KEDKDEKkKGEDEDK
0 1 K155 FGVAVQEKVFELMTS
0 1 K155‑ub FGVAVQEkVFELMTS
0 2 K176‑ub GFHTQISkYFSERGD
0 1 Y209‑p HELDEAEyRDIRLMV
0 14 K232‑ac VLYDIILkNFEKLKK
0 2 K245‑ub KKPRGETkGMIy___
0 1 Y249‑p GETkGMIy_______
0 1 - gap
  PSME1 iso2  
K13 VQPEAQAKVDVFRED
K13 VQPEAQAKVDVFRED
T23 VFREDLCTKTENLLG
K24 FREDLCTKTENLLGS
T25 REDLCTKTENLLGSY
K35 LLGSYFPKKISELDA
K35 LLGSYFPKKISELDA
K35 LLGSYFPKKISELDA
K36 LGSYFPKKISELDAF
K45 SELDAFLKEPALNEA
S55 ALNEANLSNLKAPLD
K70 IPVPDPVKEKEKEER
K90 KEDKDEKKKGEDEDK
K155 FGVAVQEKVFELMTS
K155 FGVAVQEKVFELMTS
K176 GFHTQISKYFSERGD
Y209 HELDEAEYRDIRLMV
- gap
- gap
- gap
S238‑p RGGQRQLsQATHSLT
  mouse

 
K13 VHPEAQAKVDVFRED
K13‑ub VHPEAQAkVDVFRED
S23 VFREDLCSKTENLLG
K24 FREDLCSKTENLLGS
T25 REDLCSKTENLLGSY
K35‑ac LLGSYFPkKISELDA
K35‑ub LLGSYFPkKISELDA
K35‑sc LLGSYFPkKISELDA
K36 LGSYFPkKISELDAF
K45‑ac SELDAFLkEPALNEA
S55 ALNEANLSNLKAPLD
K70‑ub IPVPDPVkEKEKEER
K90 KEEKEEKKKGDEDDK
K155‑ac FGVAVQEkVFELMTN
K155 FGVAVQEKVFELMTN
K176 GFHTQISKYFSERGD
Y209 HELDEAEYQEIRLMV
K232 VLYDIILKNFEKLKK
K245 KKPRGETKGMIY___
Y249 GETKGMIY_______
- gap
  rat

 
K13 VHPEAQAKVDVFRED
K13 VHPEAQAKVDVFRED
S23 VFREDLCSKTENLLG
K24 FREDLCSKTENLLGS
T25 REDLCSKTENLLGSY
K35 LLGSYFPKKISELDA
K35 LLGSYFPKKISELDA
K35 LLGSYFPKKISELDA
K36 LGSYFPKKISELDAF
K45 SELDAFLKEPALNEA
S55 ALNEANLSNLKAPLD
K70 IPVPDPVKEKEKEER
K90 KEEKDEKKKGDEDDK
K155 FGVAVQAKVFELMTS
K155 FGVAVQAKVFELMTS
K176 GFQTQISKYFSERGD
Y209 HELDEAEYQEIRLMV
K232 VLYDIILKNFEKLKK
K245 KKPRGETKGMIY___
Y249 GETKGMIY_______
- gap
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.