a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP3 inactivates the mitogen-activated kinases Erk2 and Jnk and is phosphorylated by ZAP-70. Phosphorylation by ZAP-70 is required for DUSP3 to inhibit the Erk2-Elk-1 pathway. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity; EC 184.108.40.206; EC 220.127.116.11
Molecular Function: MAP kinase phosphatase activity; protein kinase binding; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity
Biological Process: inactivation of MAPK activity; negative regulation of JNK cascade; negative regulation of MAPKKK cascade; negative regulation of T cell activation; negative regulation of T cell receptor signaling pathway; positive regulation of mitotic cell cycle
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.