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Protein Page:
Ku70 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Ku70 a mini-chromosome maintenance protein, essential for the initiation of eukaryotic genome replication. Allows DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.-; DNA repair, damage; EC 4.2.99.-; Nuclear receptor co-regulator; DNA-binding; Helicase; RNA-binding
Chromosomal Location of Human Ortholog: 22q13.2
Cellular Component: cytosol; membrane; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleoplasm; nucleus; transcription factor complex
Molecular Function: 5'-deoxyribose-5-phosphate lyase activity; ATP binding; ATP-dependent DNA helicase activity; damaged DNA binding; DNA binding; double-stranded DNA binding; double-stranded telomeric DNA binding; protein binding; protein C-terminus binding
Biological Process: DNA duplex unwinding; DNA ligation; DNA recombination; double-strand break repair via nonhomologous end joining; negative regulation of transcription, DNA-dependent; positive regulation of interferon type I production; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein heterotetramerization; regulation of smooth muscle cell proliferation; telomere maintenance; transcription, DNA-dependent
Reference #:  P12956 (UniProtKB)
Gene Symbols: XRCC6
Molecular weight: 69,843 Da
Basal Isoelectric point: 6.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Ku70

Protein Structure Not Found.
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Sites Implicated In
apoptosis, induced: S155‑p
apoptosis, inhibited: S27‑p, S33‑p
cell cycle regulation: S27‑p, S33‑p
DNA repair, induced: S27‑p, S33‑p
intracellular localization: S27‑p, S33‑p
phosphorylation: S155‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 S2‑p ______MsGWEsyyK
3 5 S6‑p __MsGWEsyyKTEGD
0 1 Y7‑p _MsGWEsyyKTEGDE
0 1 Y8‑p MsGWEsyyKTEGDEE
1 8 S27‑p QEENLEAsGDykYsG
0 2 Y30‑p NLEAsGDykYsGRDs
0 2 K31‑ac LEAsGDykYsGRDsL
0 1 K31‑ub LEAsGDykYsGRDsL
1 1 S33‑p AsGDykYsGRDsLIF
0 1 S37‑p ykYsGRDsLIFLVDA
0 1 S45‑p LIFLVDAsKAMFEsQ
2 0 S51‑p AsKAMFEsQSEDELT
0 1 K92‑ac VVFYGTEkDkNSVNF
0 1 K92‑m1 VVFYGTEkDkNSVNF
0 1 K92‑ub VVFYGTEkDkNSVNF
0 1 K94‑ub FYGTEkDkNSVNFkN
0 1 K100‑ac DkNSVNFkNIyVLQE
0 4 K100‑ub DkNSVNFkNIyVLQE
0 1 K100‑sc DkNSVNFkNIyVLQE
0 10 Y103‑p SVNFkNIyVLQELDN
0 13 K114‑ac ELDNPGAkRILELDQ
0 1 K114‑m1 ELDNPGAkRILELDQ
0 18 K114‑ub ELDNPGAkRILELDQ
0 1 K114‑sc ELDNPGAkRILELDQ
0 4 K123‑ub ILELDQFkGQQGQkR
0 1 K123‑sc ILELDQFkGQQGQkR
0 1 K129‑ub FkGQQGQkRFQDMMG
1 0 S155‑p WVCANLFsDVQFKMS
0 2 S180‑p DNPHGNDsAkASRAR
0 2 K182‑ub PHGNDsAkASRARTK
0 1 K207‑m1 LDLMHLKkPGGFDIS
0 2 S222‑p LFYRDIIsIAEDEDL
0 2 S237‑p RVHFEESskLEDLLR
0 5 K238‑ub VHFEESskLEDLLRK
1 1 K282‑ac NLVQKALkPPPIkLY
0 1 K282‑ub NLVQKALkPPPIkLY
0 3 K287‑ub ALkPPPIkLYREtNE
0 1 K287‑ac ALkPPPIkLYREtNE
0 1 T292‑p PIkLYREtNEPVkTK
0 1 K297‑ub REtNEPVkTKTRtFN
0 2 T302‑p PVkTKTRtFNTsTGG
0 4 S306‑p KTRtFNTsTGGLLLP
0 1 S314‑p TGGLLLPsDTkRSQI
3 44 K317‑ac LLLPsDTkRSQIYGs
0 36 K317‑ub LLLPsDTkRSQIYGs
0 2 S324‑p kRSQIYGsRQIILEk
3 3 K331‑ac sRQIILEkEETEELk
0 2 K331‑ub sRQIILEkEETEELk
0 1 K331‑sc sRQIILEkEETEELk
3 2 K338‑ac kEETEELkRFDDPGL
0 18 K338‑ub kEETEELkRFDDPGL
0 11 K351‑ub GLMLMGFkPLVLLkk
0 6 K357‑ub FkPLVLLkkHHYLRP
0 1 K357‑sc FkPLVLLkkHHYLRP
0 22 K358‑ub kPLVLLkkHHYLRPS
0 2 K392‑ac LLIKCLEkEVAALCR
0 1 T428‑p DDQKIQVtPPGFQLV
0 3 K443‑ub FLPFADDkRkMPFTE
0 2 K445‑ub PFADDkRkMPFTEkI
0 6 K451‑ub RkMPFTEkIMAtPEQ
0 1 M453 MPFTEkIMAtPEQVG
1 38 T455‑p FTEkIMAtPEQVGkM
0 8 K461‑ac AtPEQVGkMkAIVEk
0 11 K461‑ub AtPEQVGkMkAIVEk
0 1 K463‑ub PEQVGkMkAIVEkLR
0 4 K468‑ac kMkAIVEkLRFTYRs
0 3 K468‑ub kMkAIVEkLRFTYRs
0 2 S475‑p kLRFTYRsDsFENPV
1 15 S477‑p RFTYRsDsFENPVLQ
0 3 K516‑ub PKVEAMNkRLGsLVD
0 25 S520‑p AMNkRLGsLVDEFkE
0 1 K526‑ub GsLVDEFkELVyPPD
0 2 Y530‑p DEFkELVyPPDyNPE
0 1 Y534‑p ELVyPPDyNPEGkVt
3 0 K539‑ac PDyNPEGkVtkRkHD
0 1 K539‑ub PDyNPEGkVtkRkHD
0 3 T541‑p yNPEGkVtkRkHDNE
2 0 K542‑ac NPEGkVtkRkHDNEG
1 0 K544‑ac EGkVtkRkHDNEGsG
0 1 S550‑p RkHDNEGsGSkRPkV
1 0 K553‑ac DNEGsGSkRPkVEYs
0 1 K553‑ub DNEGsGSkRPkVEYs
1 0 K556‑ac GsGSkRPkVEYsEEE
0 2 K556‑ub GsGSkRPkVEYsEEE
0 7 S560‑p kRPkVEYsEEELkTH
0 3 K565‑ub EYsEEELkTHISkGT
0 2 K570‑ub ELkTHISkGTLGkFt
0 1 K570‑ac ELkTHISkGTLGkFt
0 1 K575‑ac ISkGTLGkFtVPMLk
0 2 K575‑ub ISkGTLGkFtVPMLk
0 1 T577‑p kGTLGkFtVPMLkEA
0 1 K582‑ub kFtVPMLkEACRAyG
0 1 Y588‑p LkEACRAyGLksGLK
0 11 K591‑ub ACRAyGLksGLKkQE
0 1 K591‑sc ACRAyGLksGLKkQE
0 4 S592‑p CRAyGLksGLKkQEL
0 1 K596‑ub GLksGLKkQELLEAL
0 1 T604‑p QELLEALtkHFQD__
0 5 K605‑ub ELLEALtkHFQD___
0 1 K605‑ac ELLEALtkHFQD___
  mouse

 
S2 ______MSEWEsYYK
S6‑p __MSEWEsYYKTEGE
Y7 _MSEWEsYYKTEGEE
Y8 MSEWEsYYKTEGEEE
G25 EEESPDTGGEYkYSG
Y28 SPDTGGEYkYSGRDS
K29‑ac PDTGGEYkYSGRDSL
K29 PDTGGEYKYSGRDSL
S31 TGGEYkYSGRDSLIF
S35 YkYSGRDSLIFLVDA
S43 LIFLVDASRAMFEsQ
S49‑p ASRAMFEsQGEDELT
K90 VVFYGTEKDKNSVNF
K90 VVFYGTEKDKNSVNF
K90 VVFYGTEKDKNSVNF
K92 FYGTEKDKNSVNFKN
K98 DKNSVNFKNIYVLQD
K98 DKNSVNFKNIYVLQD
K98 DKNSVNFKNIYVLQD
Y101 SVNFKNIYVLQDLDN
K112 DLDNPGAKRVLELDQ
K112 DLDNPGAKRVLELDQ
K112 DLDNPGAKRVLELDQ
K112 DLDNPGAKRVLELDQ
K121 VLELDQFKGQQGKKH
K121 VLELDQFKGQQGKKH
K127 FKGQQGKKHFRDTVG
S153 WVCANLFSDVQLKMS
S178 DDPHGRDSAKASRAR
K180 PHGRDSAKASRARTK
K205 LDLMHLKKPGGFDVS
T220 VFYRDIITTAEDEDL
S235 GVHFEESSKLEDLLR
K236 VHFEESSKLEDLLRK
K280 NLVQKANKPFPVRLY
K280 NLVQKANKPFPVRLY
R285 ANKPFPVRLYRETNE
R285 ANKPFPVRLYRETNE
T290 PVRLYRETNEPVKTK
K295 RETNEPVKTKTRTFN
T300 PVKTKTRTFNVNTGS
N304 KTRTFNVNTGSLLLP
S312 TGSLLLPSDTKRSLT
K315 LLLPSDTKRSLTYGT
K315 LLLPSDTKRSLTYGT
T322 KRSLTYGTRQIVLEK
K329 TRQIVLEKEETEELK
K329 TRQIVLEKEETEELK
K329 TRQIVLEKEETEELK
K336 KEETEELKRFDEPGL
K336 KEETEELKRFDEPGL
K349 GLILMGFKPTVMLKK
K355 FKPTVMLKKQHYLRP
K355 FKPTVMLKKQHYLRP
K356 KPTVMLKKQHYLRPS
K390 LLTKCVEKKVIAVCR
T426 DDQNIQVTPGGFQLV
K441 FLPYADDKRKVPFTE
K443 PYADDKRKVPFTEKV
K449 RKVPFTEKVtANQEQ
T451‑p VPFTEKVtANQEQID
N453 FTEKVtANQEQIDKM
K459 ANQEQIDKMKAIVQK
K459 ANQEQIDKMKAIVQK
K461 QEQIDKMKAIVQKLR
K466 KMKAIVQKLRFTYRS
K466 KMKAIVQKLRFTYRS
S473 KLRFTYRSDsFENPV
S475‑p RFTYRSDsFENPVLQ
K514 PKVEAIKKRLGsLAD
S518‑p AIKKRLGsLADEFKE
K524 GsLADEFKELVYPPG
Y528 DEFKELVYPPGYNPE
Y532 ELVYPPGYNPEGKVA
K537 PGYNPEGKVAKRKQD
K537 PGYNPEGKVAKRKQD
A539 YNPEGKVAKRKQDDE
K540 NPEGKVAKRKQDDEG
K542 EGKVAKRKQDDEGST
S548 RKQDDEGSTSKKPKV
K551 DDEGSTSKKPKVELS
K551 DDEGSTSKKPKVELS
K554 GSTSKKPKVELSEEE
K554 GSTSKKPKVELSEEE
S558 KKPKVELSEEELKAH
K563 ELSEEELKAHFRKGT
K568 ELKAHFRKGTLGKLT
K568 ELKAHFRKGTLGKLT
K573 FRKGTLGKLTVPTLK
K573 FRKGTLGKLTVPTLK
T575 KGTLGKLTVPTLKDI
K580 KLTVPTLKDICKAHG
H586 LKDICKAHGLKSGPK
K589 ICKAHGLKSGPKKQE
K589 ICKAHGLKSGPKKQE
S590 CKAHGLKSGPKKQEL
K594 GLKSGPKKQELLDAL
I602 QELLDALIRHLEKN_
R603 ELLDALIRHLEKN__
R603 ELLDALIRHLEKN__
  rat

 
S2 ______MSEWESYYK
S6 __MSEWESYYKTEGE
Y7 _MSEWESYYKTEGEE
Y8 MSEWESYYKTEGEEE
N25 EEQSPDTNGEYKYSG
Y28 SPDTNGEYKYSGRDS
K29 PDTNGEYKYSGRDSL
K29 PDTNGEYKYSGRDSL
S31 TNGEYKYSGRDSLIF
S35 YKYSGRDSLIFLVDA
S43 LIFLVDASRAMFESQ
S49 ASRAMFESQGEDELT
K90 VVFYGTEKDKNSVNF
K90 VVFYGTEKDKNSVNF
K90 VVFYGTEKDKNSVNF
K92 FYGTEKDKNSVNFKS
K98 DKNSVNFKSIYVLQD
K98 DKNSVNFKSIYVLQD
K98 DKNSVNFKSIYVLQD
Y101 SVNFKSIYVLQDLDN
K112 DLDNPGAKRVLELDR
K112 DLDNPGAKRVLELDR
K112 DLDNPGAKRVLELDR
K112 DLDNPGAKRVLELDR
K121 VLELDRFKGQQGKKH
K121 VLELDRFKGQQGKKH
K127 FKGQQGKKHFRDTIG
S153 WVCANLFSDVQFKMS
S178 DDPHGNDSAKASRAR
K180 PHGNDSAKASRARTK
K205 LDLMHLKKRGGFDVS
S220 LFYRDIISIAEDEDL
S235 GVHFEESSKLEDLLR
K236 VHFEESSKLEDLLRK
K280 NLVQKANKPFPVRLY
K280 NLVQKANKPFPVRLY
R285 ANKPFPVRLYRETNE
R285 ANKPFPVRLYRETNE
T290 PVRLYRETNEPVKTK
K295 RETNEPVKTKTRTFN
T300 PVKTKTRTFNVNTGS
N304 KTRTFNVNTGSLLLP
S312 TGSLLLPSDTKRSLT
K315 LLLPSDTKRSLTFGT
K315 LLLPSDTKRSLTFGT
T322 KRSLTFGTRQIVLEK
K329 TRQIVLEKEETEELK
K329 TRQIVLEKEETEELK
K329 TRQIVLEKEETEELK
K336 KEETEELKRFDEPGL
K336 KEETEELKRFDEPGL
K349 GLILMGFKPMVMLKN
K355 FKPMVMLKNHHYLRP
K355 FKPMVMLKNHHYLRP
N356 KPMVMLKNHHYLRPS
K390 LLTKCVEKEVIAVCR
T426 DDQNIQVTPAGFQLV
K441 FLPYADDKRKVPFTE
K443 PYADDKRKVPFTEKV
K449 RKVPFTEKVMANPEQ
M451 VPFTEKVMANPEQID
N453 FTEKVMANPEQIDKM
K459 ANPEQIDKMKAIVQK
K459 ANPEQIDKMKAIVQK
K461 PEQIDKMKAIVQKLR
K466 KMKAIVQKLRFTYRS
K466 KMKAIVQKLRFTYRS
S473 KLRFTYRSDSFENPV
S475 RFTYRSDSFENPVLQ
K514 PKVEAIKKRLGSLAD
S518 AIKKRLGSLADEFKE
K524 GSLADEFKELVYPPG
Y528 DEFKELVYPPGYNPE
Y532 ELVYPPGYNPEGKIA
K537 PGYNPEGKIAKRKAD
K537 PGYNPEGKIAKRKAD
A539 YNPEGKIAKRKADNE
K540 NPEGKIAKRKADNEG
K542 EGKIAKRKADNEGSA
S548 RKADNEGSASKKPKV
K551 DNEGSASKKPKVELs
K551 DNEGSASKKPKVELs
K554 GSASKKPKVELsEEE
K554 GSASKKPKVELsEEE
S558‑p KKPKVELsEEELKDL
K563 ELsEEELKDLFAKGT
K568 ELKDLFAKGTLGKLT
K568 ELKDLFAKGTLGKLT
K573 FAKGTLGKLTVPALR
K573 FAKGTLGKLTVPALR
T575 KGTLGKLTVPALRDI
R580 KLTVPALRDICKAYG
Y586 LRDICKAYGLKSGPK
K589 ICKAYGLKSGPKKQE
K589 ICKAYGLKSGPKKQE
S590 CKAYGLKSGPKKQEL
K594 GLKSGPKKQELLEAL
S602 QELLEALSRHLEKN_
R603 ELLEALSRHLEKN__
R603 ELLEALSRHLEKN__
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