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Protein Page:
DGCR8 (human)

Overview
DGCR8 a double strand RNA binding protein (dsRBP) which is essential for the first processing step of primary miRNAs (pri-miRNAs). Apparently binds and is activated by heme. A nuclear complex of Drosha with DGCR8 cleaves pri-miRNA substrates into 60-70 nucleotide intermediates (pre-miRNA), thus initiating the microRNA maturation process. Drosha provides the catalytic site for this cleavage, whereas DGCR8 (Pasha) anchors substrate pri-miRNAs. Pre-miRNAs are then processed by the cytoplasmic Dicer-TRBP complex to approximately 20-22 nt mature miRNAs. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; RNA processing; RNA-binding
Chromosomal Location of Human Ortholog: 22q11.2
Cellular Component: cytoplasm; microtubule cytoskeleton; nucleoplasm; nucleus
Molecular Function: double-stranded RNA binding; heme binding; protein binding; protein homodimerization activity; ribonuclease III activity
Biological Process: primary microRNA processing; RNA-mediated gene silencing
Disease: Velocardiofacial Syndrome
Reference #:  Q8WYQ5 (UniProtKB)
Alt. Names/Synonyms: C22orf12; DGCR8; DGCRK6; DiGeorge syndrome critical region 8; DiGeorge syndrome critical region gene 8; Gy1; Microprocessor complex subunit DGCR8
Gene Symbols: DGCR8
Molecular weight: 86,045 Da
Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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DGCR8

Protein Structure Not Found.
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