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Protein Page:
DGCR8 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DGCR8 a double strand RNA binding protein (dsRBP) which is essential for the first processing step of primary miRNAs (pri-miRNAs). Apparently binds and is activated by heme. A nuclear complex of Drosha with DGCR8 cleaves pri-miRNA substrates into 60-70 nucleotide intermediates (pre-miRNA), thus initiating the microRNA maturation process. Drosha provides the catalytic site for this cleavage, whereas DGCR8 (Pasha) anchors substrate pri-miRNAs. Pre-miRNAs are then processed by the cytoplasmic Dicer-TRBP complex to approximately 20-22 nt mature miRNAs. Note: This description may include information from UniProtKB.
Protein type: RNA processing; Nucleolus; RNA-binding
Chromosomal Location of Human Ortholog: 22q11.2
Cellular Component: cytoplasm; microtubule cytoskeleton; nucleolus; nucleoplasm; nucleus
Molecular Function: double-stranded RNA binding; heme binding; metal ion binding; protein binding; protein homodimerization activity; ribonuclease III activity
Biological Process: gene expression; primary microRNA processing; RNA-mediated gene silencing
Disease: Velocardiofacial Syndrome
Reference #:  Q8WYQ5 (UniProtKB)
Alt. Names/Synonyms: C22orf12; DGCR8; DGCRK6; DiGeorge syndrome critical region 8; DiGeorge syndrome critical region gene 8; Gy1; Microprocessor complex subunit DGCR8
Gene Symbols: DGCR8
Molecular weight: 86,045 Da
Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DGCR8

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: Y267‑p

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S6‑p __METDEsPsPLPCG
0 6 S8‑p METDEsPsPLPCGPA
0 1 S35‑p QALPREQsPPPPLQT
0 9 S92‑p LLIDPNCsGHsPRTA
0 21 S95‑p DPNCsGHsPRTARHA
0 10 S109‑p APAVRKFsPDLKLLK
0 1 S123‑p KDVKISVsFTESCRS
0 1 S153‑p AECGLLLsPVSGDVH
1 11 Y267‑p KRRTEEKyGGDsDHP
0 24 S271‑p EEKyGGDsDHPsDGE
0 28 S275‑p GGDsDHPsDGEtsVQ
0 3 T279‑p DHPsDGEtsVQPMMT
0 1 S280‑p HPsDGEtsVQPMMTK
0 1 S339‑p PYFLGTGsIRKHDPP
0 2 S367‑p DNEEREQssDLtPsG
0 1 S368‑p NEEREQssDLtPsGD
0 8 T371‑p REQssDLtPsGDVsP
0 16 S373‑p QssDLtPsGDVsPVK
0 30 S377‑p LtPsGDVsPVKPLsR
0 2 S383‑p VsPVKPLsRsAELEF
0 1 S385‑p PVKPLsRsAELEFPL
0 1 P404 SMGADPGPPDEKDPL
0 1 K426 ALGQVKAKVEVCKDE
0 1 T491 PANQKLITLSVQDAP
0 1 S493 NQKLITLSVQDAPTK
0 1 S545‑p PSEPFGAsVtIDGVT
0 1 T547‑p EPFGAsVtIDGVTYG
0 1 S711‑p KMVKQETsDKsVIEL
0 1 S714‑p KQETsDKsVIELQQY
  mouse

 
S6 __METYESPSPLPRE
S8 METYESPSPLPREPA
S35 QVLPHEQSPPPPLQT
S92‑p LLIDPNCsGHsPRTA
S95‑p DPNCsGHsPRTARHA
S109‑p APAVRKFsPDLKLLK
S123 KDVKISVSFTESCRS
S153 PECGQLLSPVSGDVH
Y267‑p KRRMEEKyGGDsDHP
S271‑p EEKyGGDsDHPsDGE
S275‑p GGDsDHPsDGEtSVQ
T279‑p DHPsDGEtSVQPMMT
S280 HPsDGEtSVQPMMTK
S339 PYFLGTGSIRKHDPP
N367 DNEEREQNCDLAPsG
C368 NEEREQNCDLAPsGE
A371 REQNCDLAPsGEVsP
S373‑p QNCDLAPsGEVsPVK
S377‑p LAPsGEVsPVKPLGR
G383 VsPVKPLGRSAELDF
S385 PVKPLGRSAELDFPL
S404 SMGGDSGSMDEKDPL
K426‑ac ALGQVKAkVEVCKDE
T491‑p PANQKLItLsVQDAP
S493‑p NQKLItLsVQDAPTK
S545 PSEPFGASVTIDGVT
T547 EPFGASVTIDGVTYG
S711 KMVKQETSDKSVIEL
S714 KQETSDKSVIELQQY
  rat

 
S6 __METYESPsPLPHE
S8‑p METYESPsPLPHEPT
S35 QVLPHEQSPPPPLQT
S92 LLIDPNCSGHSPRTA
S95 DPNCSGHSPRTARHA
S109 APAVRKFSPDLKLLK
S123 KDVKISVSFTESCRS
S153 PECSQLLSPVCGDVH
Y267‑p KRRMEEKyGGDsDHP
S271‑p EEKyGGDsDHPsDGE
S275‑p GGDsDHPsDGETSVQ
T279 DHPsDGETSVQPMMT
S280 HPsDGETSVQPMMTK
S339 PYFLGTGSIRKHDPP
S367 DNEEREQSCDLAPSG
C368 NEEREQSCDLAPSGE
A371 REQSCDLAPSGEVsP
S373 QSCDLAPSGEVsPVK
S377‑p LAPSGEVsPVKPLGR
G383 VsPVKPLGRSAELDF
S385 PVKPLGRSAELDFPL
S404‑p SLGGDSGsLDEKDPL
K426 ALGQVRAKVEVCKDE
T491 PANQKLITLSVQDAP
S493 NQKLITLSVQDAPTK
S545 PSEPFGASVTIDGVT
T547 EPFGASVTIDGVTYG
S711 KMVKQETSDKSVIEL
S714 KQETSDKSVIELQQY
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