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Protein Page:
ANXA7 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ANXA7 Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. Interacts with PDCD6. Isoform 1 is expressed in brain, heart and skeletal muscle. Isoform 2 is more abundant in liver, lung, kidney, spleen, fibroblasts and placenta. Belongs to the annexin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Lipid-binding; Calcium-binding
Chromosomal Location of Human Ortholog: 10q22.2
Cellular Component: endoplasmic reticulum membrane; membrane; nucleus
Molecular Function: calcium-dependent protein binding; integrin binding; protein binding
Biological Process: autophagy; epithelial cell differentiation; social behavior
Reference #:  P20073 (UniProtKB)
Alt. Names/Synonyms: Annexin A7; Annexin VII; Annexin-7; ANX7; ANXA7; SNX; Synexin
Gene Symbols: ANXA7
Molecular weight: 52,739 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ANXA7

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: T286‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K196‑ac RDAEILRkAMkGFGT
0 1 K199 EILRkAMKGFGTDEQ
0 10 K199‑ub EILRkAMkGFGTDEQ
0 1 S216‑p VDVVANRsNDQRQKI
0 2 K228 QKIKAAFKTSYGkDL
0 2 K228‑ub QKIKAAFkTSYGkDL
0 2 K233‑ac AFkTSYGkDLIkDLK
0 1 K233‑ub AFkTSYGkDLIkDLK
0 4 K237‑ub SYGkDLIkDLKSELS
2 1 T286‑p VLIEILCtRTNQEIR
0 1 K309 EFGRDLEKDIRSDTS
0 3 S336 GNRDENQSINHQMAQ
0 1 R377 TRSFPQLRATMEAYS
0 1 Y402‑p VSREFSGyVESGLKT
0 47 Y427‑p FFAERLYyAMkGAGT
0 2 K430‑ac ERLYyAMkGAGTDDS
0 5 K430‑ub ERLYyAMkGAGTDDS
0 1 S447‑p VRIVVTRsEIDLVQI
0 1 K455‑ub EIDLVQIkQMFAQMY
0 1 S475‑p TMIAGDTsGDyRRLL
0 1 Y478‑p AGDTsGDyRRLLLAI
  ANXA7 iso2  
K174 RDAEILRKAMKGFGT
K177 EILRKAMKGFGTDEQ
K177 EILRKAMKGFGTDEQ
S194 VDVVANRSNDQRQKI
K206 QKIKAAFKTSYGKDL
K206 QKIKAAFKTSYGKDL
K211 AFKTSYGKDLIKDLK
K211 AFKTSYGKDLIKDLK
K215 SYGKDLIKDLKSELS
T264 VLIEILCTRTNQEIR
K287 EFGRDLEKDIRSDTS
S314 GNRDENQSINHQMAQ
R355 TRSFPQLRATMEAYS
Y380 VSREFSGYVESGLKT
Y405 FFAERLYYAMKGAGT
K408 ERLYYAMKGAGTDDS
K408 ERLYYAMKGAGTDDS
S425 VRIVVTRSEIDLVQI
K433 EIDLVQIKQMFAQMY
S453 TMIAGDTSGDYRRLL
Y456 AGDTSGDYRRLLLAI
  mouse

 
K171 RDAEILRKAMkGFGT
K174 EILRKAMKGFGTDEQ
K174‑ub EILRKAMkGFGTDEQ
S191 VDVVSNRSNDQRQQI
K203‑ac QQIKAAFkTMYGKDL
K203‑ub QQIKAAFkTMYGKDL
K208 AFkTMYGKDLIkDLK
K208 AFkTMYGKDLIkDLK
K212‑ub MYGKDLIkDLKSELS
T261 VLIEILCTRTNQEIR
K284‑ub EFGRDLEkDIRSDTS
S311‑p GNRDERQsVNHQMAQ
K352‑ub TRSFPQLkATMEAYS
Y377 VSREFSGYVESGLKT
Y402 FFAERLYYSMkGAGT
K405 ERLYYSMKGAGTDDS
K405‑ub ERLYYSMkGAGTDDS
S422 VRIVVTRSEIDLVQI
K430 EIDLVQIKQMFTQMY
S450 TMIASDTSGDYRKLL
Y453 ASDTSGDYRKLLLAI
  rat

 
K171 RDAEILRKAMkGFGT
K174‑ac EILRKAMkGFGTDEQ
K174 EILRKAMKGFGTDEQ
S191 VDVVSNRSNDQRQQI
K203‑ac QQIKAAFkTMYGkDL
K203 QQIKAAFKTMYGkDL
K208‑ac AFkTMYGkDLIKDLK
K208 AFkTMYGKDLIKDLK
K212 MYGkDLIKDLKSELS
T261 VLIEILCTRTNQEIR
R284 EFGRELERDIRSDTS
S311 GNRDESPSINHQMAQ
R352 TRSFPQLRATMEAYS
Y377 VSREFSGYVESGLKT
Y402 FFAERLYYSMkGAGT
K405‑ac ERLYYSMkGAGTDDS
K405 ERLYYSMKGAGTDDS
S422 VRIVVTRSEIDLVQI
K430 EIDLVQIKQMFTQMY
S450 TMIASDTSGDYRKLL
Y453 ASDTSGDYRKLLLAI
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