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Protein Page:
Vinculin (rat)

Vinculin Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. Exhibits self-association properties. Interacts with NRAP and SORBS1. Interacts with TLN1. Interacts with SYNM. Interacts with CTNNB1 and this interaction is necessary for its localization to the cell-cell junctions and for its function in regulating cell surface expression of E-cadherin. Metavinculin is muscle-specific. Belongs to the vinculin/alpha-catenin family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis
Cellular Component: actin cytoskeleton; actin filament; adherens junction; brush border; cell; cell-cell adherens junction; costamere; cytoplasm; fascia adherens; focal adhesion; intercellular junction; lipid raft; plasma membrane; podosome; protein complex; sarcolemma; stress fiber; Z disc; zonula adherens
Molecular Function: actin binding; alpha-catenin binding; Rho GTPase binding; ubiquitin protein ligase binding
Biological Process: apical junction assembly; axon extension; cell adhesion; lamellipodium biogenesis; morphogenesis of an epithelium; regulation of cell migration
Reference #:  P85972 (UniProtKB)
Alt. Names/Synonyms: Metavinculin; Vcl; VINC; Vinculin
Gene Symbols: Vcl
Molecular weight: 116,615 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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