activator of cyclin-dependent kinase 5 (CDK5). Required for proper development of the central nervous system. The p35 form of this protein is cleaved by calpain, generating a p25 form, resulting in the prolonged activation and relocalization of the CDK5 from the cell periphery to nuclear and perinuclear regions. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease, leading to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. Note: This description may include information from UniProtKB.
Cellular Component: axon; cell soma; contractile fiber; cyclin-dependent protein kinase 5 activator complex; cytoplasm; cytosol; dendrite; dendritic spine; growth cone; intracellular membrane-bound organelle; membrane; neuromuscular junction; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density
Molecular Function: cadherin binding; calcium ion binding; cyclin-dependent protein kinase 5 activator activity; cyclin-dependent protein kinase activity; ephrin receptor binding; kinase activity; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activator activity
Biological Process: acetylcholine receptor signaling, muscarinic pathway; axon guidance; axonal fasciculation; brain development; cell proliferation; cerebellum development; embryonic development; ephrin receptor signaling pathway; hippocampus development; ionotropic glutamate receptor signaling pathway; layer formation in the cerebral cortex; negative regulation of axon extension; negative regulation of transcription, DNA-dependent; neurite development; neuron adhesion; neuron differentiation; neuron migration; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of neuron apoptosis; regulation of actin cytoskeleton organization and biogenesis; regulation of cyclin-dependent protein kinase activity; regulation of macroautophagy; regulation of neuron differentiation; rhythmic process; serine phosphorylation of STAT3 protein; superior olivary nucleus maturation
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.