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Protein Page:
HELLS (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HELLS Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis. By concanavalin-A in peripheral blood leukocytes. Highly expressed in proliferative tissues such as adult thymus and testis, and expressed at lower levels in uterus, small intestine, colon, and peripheral blood mononuclear cells. Also expressed in neoplastic cell lines including those derived from myeloid and lymphoid leukemias. Belongs to the SNF2/RAD54 helicase family. 9 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.-; Apoptosis; Helicase; EC 3.6.1.-
Chromosomal Location of Human Ortholog: 10q24.2
Cellular Component: centric heterochromatin; chromosome, pericentric region
Molecular Function: protein binding
Biological Process: centric heterochromatin formation; lymphocyte proliferation; maintenance of DNA methylation; methylation-dependent chromatin silencing; multicellular organismal development
Reference #:  Q9NRZ9 (UniProtKB)
Alt. Names/Synonyms: FLJ10339; helicase, lymphoid-specific; HELLS; LSH; Lymphoid-specific helicase; Nbla10143; PASG; Proliferation-associated SNF2-like protein; SMARCA6; SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6; SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 6
Gene Symbols: HELLS
Molecular weight: 97,074 Da
Basal Isoelectric point: 8.07  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HELLS

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 L21 APAMVEQLDTAVITP
0 1 T27 QLDTAVITPAMLEEE
0 1 S55 MLEKARMSWDRESTE
0 1 Y65 RESTEIRYRRLQHLL
0 3 K74‑ub RLQHLLEkSNIYSkF
0 1 K80‑ub EkSNIYSkFLLTKME
0 4 K99‑ac EEQKKKEkLERkkEs
0 4 K103‑ac KKEkLERkkEsLKVK
0 4 K104‑ac KEkLERkkEsLKVKK
0 3 S106‑p kLERkkEsLKVKKGK
0 5 S115‑p KVKKGKNsIDAsEEk
0 1 S119‑p GKNsIDAsEEkPVMR
0 1 K122‑ac sIDAsEEkPVMRKKR
0 1 K122‑ub sIDAsEEkPVMRKKR
0 1 K122‑sm sIDAsEEkPVMRKKR
0 1 S139 EDESYNISEVMSKEE
0 1 S149‑p MSKEEILsVAKKNKK
0 1 K177‑ub VEDLQKNkDSNSIIK
0 3 S188‑p SIIKDRLsEtVRQNT
0 4 T190‑p IKDRLsEtVRQNTKF
0 1 T195 sEtVRQNTKFFFDPV
0 1 K204‑ub FFFDPVRkCNGQPVP
0 1 K204‑sm FFFDPVRkCNGQPVP
0 3 Y469‑p PKREVVVyAPLsKkQ
0 2 S473‑p VVVyAPLsKkQEIFY
0 2 K475‑ub VyAPLsKkQEIFYtA
0 1 K475‑sm VyAPLsKkQEIFYtA
0 2 T481‑p KkQEIFYtAIVNRtI
0 1 T487‑p YtAIVNRtIANMFGS
0 2 T499‑p FGSSEKEtIELsPtG
0 12 S503‑p EKEtIELsPtGRPKR
0 2 T505‑p EtIELsPtGRPKRRT
0 17 S515‑p PKRRTRKsINyskID
0 2 Y518‑p RTRKsINyskIDDFP
0 2 S519‑p TRKsINyskIDDFPN
0 2 K520‑ub RKsINyskIDDFPNE
0 1 K559 VESEVNLKLQNIMML
0 1 K569‑m1 NIMMLLRkCCNHPYL
0 1 S648‑p NFSRLDGsMsysERE
0 1 S650‑p SRLDGsMsysEREKN
0 2 Y651‑p RLDGsMsysEREKNM
0 1 S652‑p LDGsMsysEREKNMH
0 1 T714‑p RCHRIGQtkPVVVYR
0 1 K715‑ub CHRIGQtkPVVVYRL
0 1 K731‑ub TANTIDQkIVERAAA
0 1 K753‑ub IIHKNHFkGGQsGLN
0 1 S757‑p NHFkGGQsGLNLSkN
0 2 K763‑ub QsGLNLSkNFLDPKE
0 1 K795‑ub REKVISDkDLELLLD
0 1 S813‑p LIDQMNAsGPIKEKM
0 2 S829‑p IFKILENsEDssPEC
0 5 S832‑p ILENsEDssPECLF_
0 4 S833‑p LENsEDssPECLF__
  mouse

 
T5‑p ___MAEQtEPAVItP
T11‑p QtEPAVItPAMLEEE
S39‑p MLEEAQKsWDRESTE
Y49‑p RESTEIRyRRLQHLL
K58 RLQHLLEKSNIYSKF
K64 EKSNIYSKFLLTKME
K83 EEQKKKEKLEKKKRs
K87 KKEKLEKKKRsLKLT
K88 KEKLEKKKRsLKLTE
S90‑p KLEKKKRsLKLTEGK
L99 KLTEGKSLVDGNGEK
N103 GKSLVDGNGEKPVMK
K106 LVDGNGEKPVMKKKR
K106 LVDGNGEKPVMKKKR
K106 LVDGNGEKPVMKKKR
S123 EDESYNISEVMSKEE
S133 MSKEEILSVAKKHKD
K160 VEDIQKNKDSNSMIK
S171‑p SMIKDRLsQTVRQNs
T173 IKDRLsQTVRQNsKF
S178‑p sQTVRQNsKFFFDPV
K187 FFFDPVRKCNGQPVP
K187 FFFDPVRKCNGQPVP
Y452‑p PKREVVVyAPLCNkQ
C456 VVVyAPLCNkQEIFY
K458‑ub VyAPLCNkQEIFYTA
K458 VyAPLCNKQEIFYTA
T464 NkQEIFYTAIVNRTI
T470 YTAIVNRTIANMFGS
T482 FGSCEKETVELsPTG
S486‑p EKETVELsPTGRPKR
T488 ETVELsPTGRPKRRS
S498‑p PKRRSRKsINysELD
Y501‑p RSRKsINysELDQFP
S502‑p SRKsINysELDQFPS
E503 RKsINysELDQFPSE
K542‑ub IESEVNLkLRNIMML
K552 NIMMLLRKCCNHPYM
S631 IFSRLDGSMSYSERE
S633 SRLDGSMSYSEREKN
Y634 RLDGSMSYSEREKNI
S635 LDGSMSYSEREKNIY
T697 RCHRIGQTKPVVVYR
K698 CHRIGQTKPVVVYRL
K714 TANTIDQKIVERAAA
K736 IIHKNHFKGGQSGLS
S740 NHFKGGQSGLSQSKN
K746 QSGLSQSKNFLDAKE
E778 REKVISDEDLELLLD
S796 LIDQMKASRPIKGKT
S812 IFKILENSEDSSAEC
S815 ILENSEDSSAECLF_
S816 LENSEDSSAECLF__
  rat

 
T21 APEMAEQTEPAVITP
T27 QTEPAVITPAMLEEE
S55 MLEEARKSWDRESTE
Y65 RESTEIRYRRLQHLL
K74 RLQHLLEKSNIYSKF
K80 EKSNIYSKFLLTKME
K99 EEQKKKEKLEKKKRS
K103 KKEKLEKKKRSLKVT
K104 KEKLEKKKRSLKVTE
S106 KLEKKKRSLKVTEGK
L115 KVTEGKNLIDGNEEN
N119 GKNLIDGNEENTVMK
N122 LIDGNEENTVMKKKR
N122 LIDGNEENTVMKKKR
N122 LIDGNEENTVMKKKR
S139‑p EDESYNIsEVMSKEE
S149 MSKEEILSVAKKHKD
K176 VEDLQKNKDSNSMIK
S187 SMIKDRLSQTVRQNS
T189 IKDRLSQTVRQNSKF
S194 SQTVRQNSKFFFDPV
K203 FFFDPVRKCNGQPVP
K203 FFFDPVRKCNGQPVP
Y468 PKREVVVYAPLCNKQ
C472 VVVYAPLCNKQEIFY
K474 VYAPLCNKQEIFYTA
K474 VYAPLCNKQEIFYTA
T480 NKQEIFYTAIVNRTI
T486 YTAIVNRTIANMFGS
T498 FGSCEKETVELsPTG
S502‑p EKETVELsPTGRPKR
T504 ETVELsPTGRPKRRS
S514‑p PKRRSRKsINYSELD
Y517 RSRKsINYSELDQFP
S518 SRKsINYSELDQFPS
E519 RKsINYSELDQFPSE
K558 IESEVNLKLQNIMML
K568 NIMMLLRKCCNHPYM
S647 TFSRLDGSMSySERE
S649 SRLDGSMSySEREKN
Y650‑p RLDGSMSySEREKNI
S651 LDGSMSySEREKNIY
T713 RCHRIGQTKPVVVYR
K714 CHRIGQTKPVVVYRL
K730 TANTIDQKIVERAAA
K752 IIHKNHFKGGQSGLS
S756 NHFKGGQSGLSQSKN
K762 QSGLSQSKNFLDAKE
E794 REKVISDEDLELLLD
S812 LIDQMKASRPIKEKT
S828 IFKILENSEDSSAEC
S831 ILENSEDSSAECLF_
S832 LENSEDSSAECLF__
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