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Protein Page:
langerin (human)

langerin Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation. Homotrimer. Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 2p13
Cellular Component: early endosome membrane; endocytic vesicle; plasma membrane
Molecular Function: carbohydrate binding; mannose binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; defense response to virus; receptor-mediated endocytosis
Disease: Birbeck Granule Deficiency
Reference #:  Q9UJ71 (UniProtKB)
Alt. Names/Synonyms: C-type lectin domain family 4 member K; C-type lectin domain family 4, member K; CD207; CD207 antigen, langerin; CD207 molecule, langerin; CLC4K; CLEC4K; Langerhans cell specific c-type lectin; Langerin
Gene Symbols: CD207
Molecular weight: 36,725 Da
Basal Isoelectric point: 8.45  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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