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Protein Page:
TLR2 (human)

Overview
TLR2 Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage- activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1. Interacts with CNPY3. Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues. Belongs to the Toll-like receptor family. Note: This description may include information from UniProtKB.
Protein type: Receptor, misc.; Apoptosis; Cell surface; Motility/polarity/chemotaxis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q32
Cellular Component: cell surface; cytoplasm; Golgi apparatus; integral to plasma membrane; intrinsic to plasma membrane; lipid raft; plasma membrane
Molecular Function: lipopolysaccharide binding; lipopolysaccharide receptor activity; pattern recognition receptor activity; peptidoglycan binding; protein binding; protein heterodimerization activity; receptor activity; triacylated lipoprotein binding
Biological Process: activation of NF-kappaB transcription factor; apoptosis; cytokine secretion during immune response; defense response to Gram-positive bacterium; detection of diacylated bacterial lipoprotein; detection of triacylated bacterial lipoprotein; I-kappaB phosphorylation; immune response; innate immune response; interleukin-10 production; MyD88-dependent toll-like receptor signaling pathway; positive regulation of chemokine production; positive regulation of inflammatory response; positive regulation of interferon-beta production; positive regulation of interleukin-12 production; positive regulation of interleukin-18 production; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of NF-kappaB import into nucleus; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of toll-like receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; positive regulation of Wnt receptor signaling pathway; signal transduction
Disease: Leprosy, Susceptibility To, 3; Mycobacterium Tuberculosis, Susceptibility To
Reference #:  O60603 (UniProtKB)
Alt. Names/Synonyms: CD282; TIL4; TLR2; Toll-like receptor 2; toll/interleukin 1 receptor-like 4; Toll/interleukin-1 receptor-like protein 4
Gene Symbols: TLR2
Molecular weight: 89,838 Da
Basal Isoelectric point: 6.17  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TLR2

Protein Structure Not Found.
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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S45‑p GSSGSLNsIPsGLTE
0 1 S48‑p GSLNsIPsGLTEAVK
0 1 Y136 LNLLGNPYKtLGEts
0 1 T138‑p LLGNPYKtLGEtsLF
0 1 T142‑p PYKtLGEtsLFSHLT
0 1 S143‑p YKtLGEtsLFSHLTK
0 1 T262‑p TFRNVKItDESLFQV
0 1 Y323‑p RLHIPRFyLFYDLST
0 2 Y653‑p SYSERDAyWVENLMV
  mouse

 
S45 GRSRSFTSIPSGLTA
S48 RSFTSIPSGLTAAMK
Y136 LNLMGNPYQTLGVTS
T138 LMGNPYQTLGVTSLF
T142 PYQTLGVTSLFPNLT
S143 YQTLGVTSLFPNLTN
T262 AFRGSVLTDESFNEL
Y323 RLHIPQFYLFYDLST
H653 SYSEQDSHWVENLMV
  rat

 
S45 GSSRSFTSIPSGLTA
S48 RSFTSIPSGLTANTK
Y136‑p LNLMGNPyRTLGETS
T138 LMGNPyRTLGETSLF
T142 PyRTLGETSLFSNLT
S143 yRTLGETSLFSNLTN
T262 AFRNADLTDKSFNEL
Y323 SLHIPQFYLFYDLST
Y653 SYSEQDSYWVENLMV
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