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Protein Page:
NOV (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NOV Immediate-early protein likely to play a role in cell growth regulation. Belongs to the CCN family. Expression is down-regulated by WT1. Interacts with FBLN1. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 8q24.1
Cellular Component: axon; cell soma; cytoplasm; dendrite; extracellular region; gap junction; intracellular membrane-bound organelle; proteinaceous extracellular matrix
Molecular Function: growth factor activity; heparin binding; insulin-like growth factor binding; integrin binding; Notch binding; protein binding
Biological Process: angiogenesis; cell adhesion mediated by integrin; cell-cell signaling; chondrocyte differentiation; negative regulation of cell growth; negative regulation of inflammatory response; negative regulation of insulin secretion; negative regulation of NF-kappaB import into nucleus; positive regulation of Notch signaling pathway; regulation of gene expression; signal transduction; smooth muscle cell migration; smooth muscle cell proliferation
Reference #:  P48745 (UniProtKB)
Alt. Names/Synonyms: CCN family member 3; CCN3; IBP-9; IGF-binding protein 9; IGFBP-9; IGFBP9; Insulin-like growth factor-binding protein 9; nephroblastoma overexpressed gene; Nephroblastoma-overexpressed gene protein homolog; NOV; NOVH; Protein NOV homolog
Gene Symbols: NOV
Molecular weight: 39,162 Da
Basal Isoelectric point: 8.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NOV

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T46‑ga CPGRCPAtPPtCAPG
0 1 T49‑ga RCPAtPPtCAPGVRA
0 1 S225‑p KSCGMGFstRVTNRN
0 1 T226‑p SCGMGFstRVTNRNR
0 1 S316‑p IQAEFQCsPGQIVKK
0 1 T352‑ga LQELELKttRGKM__
0 1 T353‑ga QELELKttRGKM___
  mouse

 
I40 CPPKCPSISPTCAPG
T43 KCPSISPTCAPGVRS
S222 KSCGMGVSTRVTNRN
T223 SCGMGVSTRVTNRNR
L313 IQVEFQCLPGEIIKK
T349 LQDLELKTSRGEI__
S350 QDLELKTSRGEI___
  rat

 
I40 CPSQCPSISPTCAPG
T43 QCPSISPTCAPGVRS
S219 KSCGMGLSTRVTNRN
T220 SCGMGLSTRVTNRNL
L310 IQVEFQCLPGQIIKK
T346 LQELELKTSRGEM__
S347 QELELKTSRGEM___
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