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Protein Page:
ATP13A2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ATP13A2 May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Expressed in brain; protein levels are markedly increased in brain from subjects with Parkinson disease and subjects with dementia with Lewy bodies. Detected in pyramidal neurons located throughout the cingulate cortex. In the substantia nigra, it is found in neuromelanin- positive dopaminergic neurons. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Hydrolase; EC 3.6.3.-; Transporter, ion channel
Chromosomal Location of Human Ortholog: 1p36
Cellular Component: autophagic vacuole; cell soma; integral to plasma membrane; late endosome; lysosomal lumen; lysosomal membrane; lysosome; multivesicular body; neuron projection; transport vesicle; vesicle
Molecular Function: cation-transporting ATPase activity; manganese ion binding; protein binding; zinc ion binding
Biological Process: cellular calcium ion homeostasis; cellular cation homeostasis; cellular iron ion homeostasis; cellular zinc ion homeostasis; positive regulation of protein secretion; protein amino acid autophosphorylation; regulation of autophagic vacuole size; regulation of endopeptidase activity; regulation of macroautophagy; zinc ion homeostasis
Disease: Kufor-rakeb Syndrome
Reference #:  Q9NQ11 (UniProtKB)
Alt. Names/Synonyms: AT132; ATP13A2; ATPase type 13A2; FLJ26510; HSA9947; KRPPD; PARK9; Probable cation-transporting ATPase 13A2; putative ATPase
Gene Symbols: ATP13A2
Molecular weight: 128,794 Da
Basal Isoelectric point: 8.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ATP13A2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K68‑ub PLLLFRWkPLWGVRL
0 2 K143‑ub AVPEGAWkDTAQLHk
0 1 K150‑ub kDTAQLHksEEAVSV
0 4 S151‑p DTAQLHksEEAVSVG
0 1 Y165‑p GQKRVLRyYLFQGQR
0 1 K213 LQDQMVRKAIYGPNV
0 1 G362 TALPEGLGPYCAETH
0 1 K506 LRINLGGKLQLVCFD
0 2 K693‑ub RVVALASkPLPTVPS
0 1 K804‑ub PTAVNGVkDPDQAAS
0 2 K839‑ub IIVKHFPkLLPkVLV
0 1 K843‑ub HFPkLLPkVLVQGTV
  mouse

 
K68 PWLLFRWKPLWGVRL
Q143 VTPEGTWQDTSELHR
R150 QDTSELHRQEEAKQV
Q151 DTSELHRQEEAKQVL
Y160 EAKQVLRYYVLQGQR
K208‑ub LQDQATRkTIYGPNV
K357‑ub TALPEGPkPYCPETH
K501‑ub LRINLGGkLRLVCFD
K686‑ub RVVALAGkPLPIAPS
K797 SAVMNGAKATGYPTV
K828‑ub VLRKHFPkLLPKVLV
K832 HFPkLLPKVLVQATV
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