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Protein Page:
PDPN (human)

PDPN May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels. Belongs to the podoplanin family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p36.21
Cellular Component: filopodium; integral to plasma membrane; lamellipodium; plasma membrane; ruffle
Molecular Function: amino acid transmembrane transporter activity; folic acid transporter activity; water channel activity; water transporter activity
Biological Process: amino acid transport; cell morphogenesis; cell motility involved in cell locomotion; folic acid transport; lung development; lymphangiogenesis; platelet activation; positive regulation of cell motility; water transport
Reference #:  Q86YL7 (UniProtKB)
Alt. Names/Synonyms: Aggrus; Glycoprotein 36; glycoprotein, 36-KD; GP36; Gp38; GP40; HT1A-1; hT1alpha-1; hT1alpha-2; lung type I cell membrane associated glycoprotein; lung type-I cell membrane-associated glycoprotein; lung type-I cell membrane-associated glycoprotein (T1A-2); OTS8; PA2.26; PA2.26 antigen; PDPN; Podoplanin; T1-alpha; T1A; T1A-2
Gene Symbols: PDPN
Molecular weight: 16,698 Da
Basal Isoelectric point: 4.37  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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