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Protein Page:
KSR (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
KSR a serine/threonine kinase of the Raf family with no demonstrated kinase activity. A location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. Interacts with RAF and MAPK/ERK, in a Ras-dependent manner. The binding of 14-3-3 proteins to phosphorylated KSR prevents the membrane localization. In unstimulated cells, the phosphorylated form is bound to a 14-3-3 protein and sequestered in the cytoplasm. Translocates from the cytoplasm to the cell periphery following TNF treatment. When Bad is available, ceramide signaling through the Ras/Raf cascade can lead to apoptosis. Three alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); TKL group; RAF family
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; protein complex
Molecular Function: ATP binding; MAP-kinase scaffold activity; metal ion binding; mitogen-activated protein kinase kinase binding; protein binding; protein C-terminus binding; protein kinase activity
Biological Process: activation of MAPKK activity; axon guidance; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; nerve growth factor receptor signaling pathway; Ras protein signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway
Reference #:  Q8IVT5 (UniProtKB)
Alt. Names/Synonyms: kinase suppressor of ras; Kinase suppressor of Ras 1; KSR; KSR1; RSU2
Gene Symbols: KSR1
Molecular weight: 102,160 Da
Basal Isoelectric point: 8.94  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

KSR

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S54 LIDISIGSLRGLRTK
0 3 Y162‑p DECGRLQyALTCLRK
0 1 S184‑p HKEDSSWsSLDARRE
0 1 S202‑p GPSTDTLsAASLPWP
0 1 S229‑p AQGPRSIsVSALPAS
0 3 S238‑p SALPASDsPtPSFsE
0 1 T240‑p LPASDsPtPSFsEGL
0 1 S244‑p DsPtPSFsEGLSDtC
0 3 T250‑p FsEGLSDtCIPLHAs
0 3 S257‑p tCIPLHAsGRLtPRA
0 1 T261‑p LHAsGRLtPRALHsF
0 7 S267‑p LtPRALHsFItPPtt
0 65 T270‑p RALHsFItPPttPQL
0 12 T273‑p HsFItPPttPQLRRH
3 40 T274‑p sFItPPttPQLRRHT
4 5 T288‑p TKLKPPRtPPPPsRK
0 3 S293‑p PRtPPPPsRKVFQLL
0 2 S309‑p SFPTLTRsKsHEsQL
2 19 S311‑p PTLTRsKsHEsQLGN
0 1 S314‑p TRsKsHEsQLGNRID
0 3 S331‑p SSMRFDLsHGsPQMV
1 19 S334‑p RFDLsHGsPQMVRRD
0 1 S351‑p LSVTHRFsTKSWLSQ
0 15 T404‑p PLTRLRRtEsVPsDI
7 102 S406‑p TRLRRtEsVPsDINN
0 4 S409‑p RRtEsVPsDINNPVD
0 16 T425‑p AAEPHFGtLPKALTK
1 0 S449 LDSSSNPSSTTSSTP
2 0 S458 TTSSTPSSPAPFPTS
0 1 T473‑p SNPSSATtPPNPsPG
1 1 S478‑p ATtPPNPsPGQRDSR
0 9 N487 GQRDSRFNFPAAYFI
0 1 S528 KENAFNISAFAHAAP
0 18 S569‑p EEPEAGKsEAEDDED
0 2 S597‑p GPISRKAsQtSVYLQ
1 2 T599‑p ISRKAsQtSVYLQEW
1 0 S600 SRKAsQtSVYLQEWD
1 0 Y602 KAsQtSVYLQEWDIP
0 2 K656‑ac DHLKLFKkEVMNYRQ
0 1 K709‑ac KTSLDINkTRQIAQE
0 1 Y723‑p EIIKGMGyLHAKGIV
1 0 Y778 LSHDWLCYLAPEIVR
0 1 T844‑p EGMKRVLtSVSLGKE
1 5 S888‑p PKLNRRLsHPGHFWK
  KSR iso2  
S54 LIDISIGSLRGLRTK
Y162 DECGRLQYALTCLRK
S184 HKEDSSWSSLDARRE
S202 GPSTDTLSAASLPWP
S229 AQGPRSISVSALPAS
S238 SALPASDSPTPSFSE
T240 LPASDSPTPSFSEGL
S244 DSPTPSFSEGLSDTC
T250 FSEGLSDTCIPLHAS
S257 TCIPLHASGRLTPRA
T261 LHASGRLTPRALHSF
S267 LTPRALHSFITPPTT
T270 RALHSFITPPTTPQL
T273 HSFITPPTTPQLRRH
T274 SFITPPTTPQLRRHT
T288 TKLKPPRTPPPPSRK
S293 PRTPPPPSRKVFQLL
S309 SFPTLTRSKSHESQL
S311 PTLTRSKSHESQLGN
S314 TRSKSHESQLGNRID
S331 SSMRFDLSHGSPQMV
S334 RFDLSHGSPQMVRRD
S351 LSVTHRFSTKSWLSQ
T404 PLTRLRRTESVPSDI
S406 TRLRRTESVPSDINN
S409 RRTESVPSDINNPVD
T425 AAEPHFGTLPKALTK
S449 LDSSSNPSSTTSSTP
S458 TTSSTPSSPAPFPTS
T473 SNPSSATTPPNPSPG
S478 ATTPPNPSPGQRDSR
N487 GQRDSRFNFPAAYFI
S506 QFIFPDISAFAHAAP
S547 EEPEAGKSEAEDDED
S575 GPISRKASQTSVYLQ
T577 ISRKASQTSVYLQEW
S578 SRKASQTSVYLQEWD
Y580 KASQTSVYLQEWDIP
K634 DHLKLFKKEVMNYRQ
K687 KTSLDINKTRQIAQE
Y701 EIIKGMGYLHAKGIV
Y756 LSHDWLCYLAPEIVR
T822 EGMKRVLTSVSLGKE
S866 PKLNRRLSHPGHFWK
  KSR iso4  
- gap
Y25 DECGRLQYALTCLRK
S47 HKEDSSWSSLDARRE
S65 GPSTDTLSAASLPWP
S92 AQGPRSISVSALPAS
S101 SALPASDSPTPSFSE
T103 LPASDSPTPSFSEGL
S107 DSPTPSFSEGLSDTC
T113 FSEGLSDTCIPLHAS
S120 TCIPLHASGRLTPRA
T124 LHASGRLTPRALHSF
S130 LTPRALHSFITPPTT
T133 RALHSFITPPTTPQL
T136 HSFITPPTTPQLRRH
T137 SFITPPTTPQLRRHT
T151 TKLKPPRTPPPPSRK
S156 PRTPPPPSRKVFQLL
S172 SFPTLTRSKSHESQL
S174 PTLTRSKSHESQLGN
S177 TRSKSHESQLGNRID
S194 SSMRFDLSHGSPQMV
S197 RFDLSHGSPQMVRRD
S214 LSVTHRFSTKSWLSQ
T267 PLTRLRRTESVPSDI
S269 TRLRRTESVPSDINN
S272 RRTESVPSDINNPVD
T288 AAEPHFGTLPKALTK
S312 LDSSSNPSSTTSSTP
S321 TTSSTPSSPAPFPTS
T336 SNPSSATTPPNPSPG
S341 ATTPPNPSPGQRDSR
N350 GQRDSRFNFPAAYFI
S391 KENAFNISAFAHAAP
S432 EEPEAGKSEAEDDED
S460 GPISRKASQTSVYLQ
T462 ISRKASQTSVYLQEW
S463 SRKASQTSVYLQEWD
Y465 KASQTSVYLQEWDIP
K519 DHLKLFKKEVMNYRQ
K572 KTSLDINKTRQIAQE
Y586 EIIKGMGYLHAKGIV
Y641 LSHDWLCYLAPEIVR
T707 EGMKRVLTSVSLGKE
S751 PKLNRRLSHPGHFWK
  mouse

 
S52‑p LIDISIGsLRGLRTK
Q160 EECSRLQQALTCLRK
S182 HKMDSGWSSTDARDS
- gap
S215 TQGPRSISVSALPAS
S224 SALPASDSPVPGLSE
V226 LPASDSPVPGLSEGL
S230 DSPVPGLSEGLSDsC
S236‑p LSEGLSDsCIPLHTS
S243 sCIPLHTSGRLTPRA
T247 LHTSGRLTPRALHsF
S253‑p LTPRALHsFItPPtt
T256‑p RALHsFItPPttPQL
T259‑p HsFItPPttPQLRRH
T260‑p sFItPPttPQLRRHA
T274‑p AKLKPPRtPPPPsRK
S279‑p PRtPPPPsRKVFQLL
S295‑p SFPTLTRsKsHESQL
S297‑p PTLTRsKsHESQLGN
S300 TRsKsHESQLGNRID
P317 TPMKFELPHGsPQLV
S320‑p KFELPHGsPQLVRRD
S337 LSVTHRFSTKSWLSQ
T390‑p PLARLRRtEsVPsDI
S392‑p ARLRRtEsVPsDINN
S395‑p RRtEsVPsDINNPVD
T411‑p AAEPHFGtLPKALTK
S434‑p LDSSSNPsSTTSSTP
S443‑p TTSSTPSsPAPFLTS
T458 SNPSSATTPPNPsPG
S463‑p ATTPPNPsPGQRDSR
S472‑p GQRDSRFsFPDIsAC
S477‑p RFsFPDIsACSQAAP
S518‑p EEPEAGKsEAEDDEE
S547 GPISRKASQtsVyLQ
T549‑p ISRKASQtsVyLQEW
S550‑p SRKASQtsVyLQEWD
Y552‑p KASQtsVyLQEWDIP
K606 DHLKLFKKEVMNYRQ
K659 KTSLDINKTRQIAQE
Y673 EIIKGMGYLHAKGIV
Y728‑p LSHDWLCyLAPEIVR
A794 EGVRRVLASVSLGKE
S838‑p PKLNRRLsHPGHFWK
4951 : Phospho-KSR1 (Ser392) Antibody
  rat

 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T38 PLARLRRTEsVPSDI
S40‑p ARLRRTEsVPSDINN
S43 RRTEsVPSDINNPVD
T59 AAEPHFGTLPKALTK
S82 LDSSSNPSSTTSSTP
S91 TTSSTPSSPAPFLTS
T106 SNPSSATTPPNPSPG
S111 ATTPPNPSPGQRDSR
N120 GQRDSRFNFPDISAC
S125 RFNFPDISACPQAAP
S166‑p EEPEAGKsEAEDDED
S194 GPISRKASQTSVYLQ
T196 ISRKASQTSVYLQEW
S197 SRKASQTSVYLQEWD
Y199 KASQTSVYLQEWDIP
K253 DHLKLFKKEVMNYRQ
K306 KTSLDINKTRQIAQE
Y320 EIIKGMGYLHAKGIV
Y375 LSHDWLCYLAPEIVR
A441 EGVKRVLASVSLGKE
S485 PKLNRRLSHPGHFWK
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