Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
IRAK3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IRAK3 a TKL kinase of the IRAK family. The interleukin-1 receptor-associated kinases are important mediators in the signal transduction of Toll-like receptor and IL1R family members, collectively referred to as TIRs. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; Protein kinase, TKL; TKL group; IRAK family
Chromosomal Location of Human Ortholog: 12q14.3
Cellular Component: cytoplasm; nucleus
Molecular Function: ATP binding; magnesium ion binding; protein heterodimerization activity; protein homodimerization activity; protein serine/threonine kinase activity
Biological Process: activation of NF-kappaB transcription factor; cytokine and chemokine mediated signaling pathway; inhibition of NF-kappaB transcription factor; MyD88-dependent toll-like receptor signaling pathway; negative regulation of cytokine and chemokine mediated signaling pathway; negative regulation of innate immune response; negative regulation of interleukin-12 production; negative regulation of interleukin-6 production; negative regulation of MAP kinase activity; negative regulation of protein catabolic process; negative regulation of protein complex disassembly; negative regulation of toll-like receptor signaling pathway; negative regulation of tumor necrosis factor production; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of protein complex disassembly; response to exogenous dsRNA; response to lipopolysaccharide; response to peptidoglycan; response to virus
Disease: Asthma-related Traits, Susceptibility To, 5
Reference #:  Q9Y616 (UniProtKB)
Gene Symbols: IRAK3
Molecular weight: 67,767 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
CST Pathways:  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IRAK3

Protein Structure Not Found.


STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 S51 LAERLSSSWLDVRHI
0 1 Y61‑p DVRHIEKyVDQGKsG
0 1 S67‑p KyVDQGKsGTRELLW
0 3 S110‑p TNYGAVLsPSEKSYQ
0 1 S154‑p ILLKSSIsFQNIIEG
0 1 T162‑p FQNIIEGtRNFHKDF
0 1 T188‑p RVEIQNLtyAVKLFK
0 1 Y189‑p VEIQNLtyAVKLFKQ
0 1 K199‑ac KLFKQEKkMQCKKHW
0 1 K379‑ub RVVLDDPkHIQLRDL
0 1 S398‑p MEKRGLDsCLsFLDK
0 1 S401‑p RGLDsCLsFLDKKVP
0 3 S467‑p LKSFRCPsPLFLENV
0 1 S484‑p IPVEDDEsQNNNLLP
0 2 S510‑p QKTPFECsQsEVMFL
0 1 S512‑p TPFECsQsEVMFLSL
0 1 S582 RPVESSCSSKFSWDE
0 1 S583 PVESSCSSKFSWDEY
0 1 D588 CSSKFSWDEYEQYKK
  IRAK3 iso2  
- gap
- gap
- gap
S49‑p RGLGAVLsPSEKSYQ
S93 ILLKSSISFQNIIEG
T101 FQNIIEGTRNFHKDF
T127 RVEIQNLTYAVKLFK
Y128 VEIQNLTYAVKLFKQ
K138 KLFKQEKKMQCKKHW
K318 RVVLDDPKHIQLRDL
S337 MEKRGLDSCLSFLDK
S340 RGLDSCLSFLDKKVP
S406 LKSFRCPSPLFLENV
S423 IPVEDDESQNNNLLP
S449 QKTPFECSQSEVMFL
S451 TPFECSQSEVMFLSL
S521 RPVESSCSSKFSWDE
S522 PVESSCSSKFSWDEY
D527 CSSKFSWDEYEQYKK
  mouse

 
S51‑p LAERLSNsWLDVRHI
Y61 DVRHIEKYVNQGKSG
S67 KYVNQGKSGTRELLW
T110 INYGVSWTPSVQTHH
S167 TLQKTPISFQSILEG
T175 FQSILEGTKHFHKDF
A201 RVDIRNQAYAVKLFK
Y202 VDIRNQAYAVKLFKQ
K212 KLFKQEKKMQLKKHW
K392 KVVLDDPKHVQLRDL
S411 MEKRGLDSCLSFLDR
S414 RGLDSCLSFLDRKIP
S480‑p LKSFRCPsPLFLDNV
N497 IPVEDDENQNNHSVP
S523‑p QKTPFECsQSEVTFL
S525 TPFECsQSEVTFLGL
S595‑p KPMEKRCssGLFCsE
S596‑p PMEKRCssGLFCsEH
S601‑p CssGLFCsEHEQSKK
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.