a receptor tyrosine kinase of the TRK family. Receptor for neurotrophin-3 (NT-3). Known substrates for the trk receptors are SHC, PI-3 kinase, and PLCG1. Four alternatively spliced isoforms are known. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Kinase, protein; EC 18.104.22.168; Protein kinase, tyrosine (receptor); Protein kinase, TK; TK group; Trk family
Cellular Component: cytoplasm; integral to plasma membrane; receptor complex
Molecular Function: ATP binding; GPI-linked ephrin receptor activity; neurotrophin binding; neurotrophin receptor activity; p53 binding; protein binding
Biological Process: activation of MAPK activity; activation of protein kinase B; circadian rhythm; ephrin receptor signaling pathway; heart development; mechanoreceptor differentiation; modification by virus of host cell transcription; negative regulation of astrocyte differentiation; negative regulation of protein amino acid phosphorylation; neuron fate specification; neuron migration; peptidyl-tyrosine phosphorylation; positive regulation of apoptosis; positive regulation of axon extension involved in regeneration; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of peptidyl-serine phosphorylation; positive regulation of positive chemotaxis; positive regulation of protein amino acid phosphorylation; positive regulation of synaptogenesis; protein amino acid autophosphorylation; response to axon injury; response to corticosterone stimulus; response to ethanol; transmembrane receptor protein tyrosine kinase signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.