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Protein Page:
TrkC (human)

Overview
TrkC a receptor tyrosine kinase of the TRK family. Receptor for neurotrophin-3 (NT-3). Known substrates for the trk receptors are SHC, PI-3 kinase, and PLCG1. Four alternatively spliced isoforms are known. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; Protein kinase, tyrosine (receptor); Kinase, protein; Membrane protein, integral; EC 2.7.10.1; TK group; Trk family
Chromosomal Location of Human Ortholog: 15q25
Cellular Component: cytoplasm; integral to plasma membrane; receptor complex
Molecular Function: ATP binding; GPI-linked ephrin receptor activity; neurotrophin binding; neurotrophin receptor activity; p53 binding; protein binding
Biological Process: activation of MAPK activity; activation of protein kinase B; circadian rhythm; ephrin receptor signaling pathway; heart development; mechanoreceptor differentiation; modification by virus of host cell transcription; negative regulation of astrocyte differentiation; negative regulation of protein amino acid phosphorylation; neuron fate specification; neuron migration; peptidyl-tyrosine phosphorylation; positive regulation of apoptosis; positive regulation of axon extension involved in regeneration; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of peptidyl-serine phosphorylation; positive regulation of positive chemotaxis; positive regulation of protein amino acid phosphorylation; positive regulation of synaptogenesis; protein amino acid autophosphorylation; response to axon injury; response to corticosterone stimulus; response to ethanol; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q16288 (UniProtKB)
Alt. Names/Synonyms: ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion partner; gp145(trkC); GP145-TrkC; Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; neurotrophin 3 receptor; NT-3 growth factor receptor; NTRK3; Trk-C; TRKC; TrkC tyrosine kinase; tyrosine kinase receptor C
Gene Symbols: NTRK3
Molecular weight: 94,428 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TrkC

Protein Structure Not Found.
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Sites Implicated In
cell growth, altered: Y516‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 Y131‑p AKNPHLRyINLSSNR
0 1 T141 LSSNRLTTLSWQLFQ
0 1 S151 WQLFQTLSLRELQLE
0 1 T220‑p SVSHVNLtVREGDNA
0 1 T386‑p IAKNPLGtANQTING
0 1 S479 SGEEDSASPLHHINH
0 1 S493 HGITTPSSLDAGPDT
2 71 Y516‑p PVIENPQyFRQGHNC
0 4 Y558‑p KVFLAECyNLSPTKD
0 4 S561 LAECyNLSPTKDKML
1 48 Y705‑p FGMSRDVySTDyyRL
0 2 S706 GMSRDVySTDyyRLF
1 29 Y709‑p RDVySTDyyRLFNPS
1 9 Y710‑p DVySTDyyRLFNPSG
0 2 Y800‑p RVCPKEVyDVMLGCW
2 0 Y834 LGKATPIYLDILG__
0 3 - gap
0 9 - gap
0 1 - gap
0 1 - gap
0 1 - gap
  TrkC iso2  
Y131 AKNPHLRYINLSSNR
T141 LSSNRLTTLSWQLFQ
S151 WQLFQTLSLRELQLE
T220 SVSHVNLTVREGDNA
T386 IAKNPLGTANQTING
S479 SGEEDSASPLHHINH
S493 HGITTPSSLDAGPDT
Y516 PVIENPQYFRQGHNC
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
Y555 HLVPSTHYIYEEPEV
Y557 VPSTHYIYEEPEVQS
Y597‑p KPLNHGIyVEDVNVy
Y604‑p yVEDVNVyFsKGRHG
S606‑p EDVNVyFsKGRHGF_
  mouse

 
Y131 AKNPHLRYINLSSNR
T141‑p LSSNRLTtLSWQLFQ
S151‑p WQLFQTLsLRELRLE
T220 SVSHVNLTVREGDNA
T386 IAKNALGTANQTING
S479‑p SGEEDSAsPLHHINH
S493‑p HGITTPSsLDAGPDT
Y516‑p PVIENPQyFRQGHNC
Y558 KVFLAECYNLsPTKD
S561‑p LAECYNLsPTKDKML
Y705‑p FGMSRDVysTDyyRV
S706‑p GMSRDVysTDyyRVG
Y709‑p RDVysTDyyRVGGHT
Y710‑p DVysTDyyRVGGHTM
Y786 RVCPKEVYDVMLGCW
Y820‑p LGKATPIyLDILG__
- gap
- gap
- gap
- gap
- gap
  rat

► Hide Isoforms
 
Y131 AKNPHLRYINLSSNR
T141 LSSNRLTTLSWQLFQ
S151 WQLFQTLSLRELRLE
T220 SVSHVNLTVREGDNA
T386 IAKNALGTANQTING
S479 SGEEDSASPLHHINH
S493 HGITTPSSLDAGPDT
Y516‑p PVIENPQyFRQGHNC
Y558‑p KVFLAECyNLSPTKD
S561 LAECyNLSPTKDKML
Y705‑p FGMSRDVySTDyyRE
S706 GMSRDVySTDyyREG
Y709‑p RDVySTDyyREGPYQ
Y710‑p DVySTDyyREGPYQK
Y825 RVCPKEVYDVMLGCW
Y859‑p LGKATPIyLDILG__
- gap
- gap
- gap
- gap
- gap
  TrkC iso2  
Y131 AKNPHLRYINLSSNR
T141 LSSNRLTTLSWQLFQ
S151 WQLFQTLSLRELRLE
T220 SVSHVNLTVREGDNA
T386 IAKNALGTANQTING
S479 SGEEDSASPLHHINH
S493 HGITTPSSLDAGPDT
Y516‑p PVIENPQyFRQGHNC
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
Y555‑p HLVPSTHyIyEEPEV
Y557‑p VPSTHyIyEEPEVQS
Y597 KPLNHGIYVEDVNVY
Y604 YVEDVNVYFSKGRHG
S606 EDVNVYFSKGRHGF_
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