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Protein Page:
GAD2 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GAD2 Catalyzes the production of GABA. Homodimer. Belongs to the group II decarboxylase family. Note: This description may include information from UniProtKB.
Protein type: Other Amino Acids Metabolism - beta-alanine; Amino Acid Metabolism - alanine, aspartate and glutamate; Other Amino Acids Metabolism - taurine and hypotaurine; Carbohydrate Metabolism - butanoate; EC 4.1.1.15; Lyase
Chromosomal Location of Human Ortholog: 10p11.23
Cellular Component: axon; cell junction; cytosol; Golgi membrane; perinuclear region of cytoplasm; plasma membrane; presynaptic membrane; synaptic vesicle membrane
Molecular Function: glutamate binding; glutamate decarboxylase activity; protein binding; protein heterodimerization activity; pyridoxal phosphate binding
Biological Process: glutamate decarboxylation to succinate; neurotransmitter biosynthetic process; neurotransmitter secretion; response to drug; synaptic transmission
Reference #:  Q05329 (UniProtKB)
Alt. Names/Synonyms: 65 kDa glutamic acid decarboxylase; DCE2; GAD-65; GAD2; GAD65; Glutamate decarboxylase 2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Glutamate decarboxylase 65 kDa isoform; Glutamate decarboxylase-2 (pancreas); MGC161605; MGC161607
Gene Symbols: GAD2
Molecular weight: 65,411 Da
Basal Isoelectric point: 6.45  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GAD2

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 3 S3‑p _____MAsPGsGFWs
2 0 S6‑p __MAsPGsGFWsFGs
1 1 S10‑p sPGsGFWsFGsEDGS
1 1 S13‑p sGFWsFGsEDGSGDS
0 1 K54 LLYGDAEKPAESGGS
0 1 K54 LLYGDAEKPAESGGS
0 1 S61 KPAESGGSQPPRAAA
0 8 K78 AACACDQKPCSCSKV
1 0 - under review  
0 1 Y169‑p HCQTTLKyAIKTGHP
0 5 K286 EHSHFSLKKGAAALG
0 1 T296‑p AAALGIGtDsVILIK
0 1 S298‑p ALGIGtDsVILIKCD
1 0 - under review  
0 1 T515‑p YIPPSLRtLEDNEER
0 1 S546‑p EYGTTMVsyQPLGDK
0 1 Y547‑p YGTTMVsyQPLGDKV
  mouse

 
S3‑p _____MAsPGSGFWs
S6 __MAsPGSGFWsFGS
S10‑p sPGSGFWsFGSEDGS
S13 SGFWsFGSEDGSADP
K54 LLYGDSGKPAEGGGs
K54‑ub LLYGDSGkPAEGGGs
S61‑p kPAEGGGsVTSRAAT
K78‑ub VACTCDQkPCNCPKG
- under review  
Y169 HCQTTLKYAIKTGHP
K286‑ac EHSHFSLkKGAAALG
T296 AAALGIGTDSVILIK
S298 ALGIGTDSVILIKCD
- under review  
T515 FVPPSLRTLEDNEER
S546 EYGTTMVSYQPLGDK
Y547 YGTTMVSYQPLGDKV
  rat

 
S3‑p _____MAsPGsGFWs
S6‑p __MAsPGsGFWsFGs
S10‑p sPGsGFWsFGsEDGS
S13‑p sGFWsFGsEDGSGDP
K54‑ac LLYGDSEkPAESGGS
K54 LLYGDSEKPAESGGS
S61 kPAESGGSVTSRAAT
K78‑ub VACTCDQkPCSCPKG
T95‑p NYALLHAtDLLPACE
Y169 HCQTTLKYAIKTGHP
K286 EHSHFSLKKGAAALG
T296 AAALGIGTDSVILIK
S298 ALGIGTDSVILIKCD
S417‑p REEGLMQsCNQMHAS
V515 FVPPSLRVLEDNEER
S546 EYGTTMVSYQPLGDK
Y547 YGTTMVSYQPLGDKV
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