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Protein Page:
TrkB (human)

TrkB a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Trk family
Chromosomal Location of Human Ortholog: 9q22.1
Cellular Component: integral to plasma membrane; receptor complex
Molecular Function: brain-derived neurotrophic factor binding; brain-derived neurotrophic factor receptor activity; neurotrophin binding; protein homodimerization activity
Biological Process: brain-derived neurotrophic factor receptor signaling pathway; central nervous system neuron development; cerebral cortex development; learning; negative regulation of neuron apoptosis; neuron differentiation; neuron migration; positive regulation of axonogenesis; positive regulation of cell proliferation; positive regulation of MAPKKK cascade; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid phosphorylation; protein amino acid autophosphorylation; regulation of GTPase activity
Disease: Obesity, Hyperphagia, And Developmental Delay
Reference #:  Q16620 (UniProtKB)
Alt. Names/Synonyms: BDNF-tropomyosine receptor kinase B; BDNF/NT-3 growth factors receptor; GP145-TrkB; Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 2; NTRK2; Trk-B; TRKB; TrkB tyrosine kinase; tyrosine kinase receptor B
Gene Symbols: NTRK2
Molecular weight: 91,999 Da
Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
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