Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity. Expressed in the developing nail bed mesenchyme. Belongs to the Msh homeobox family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis
Biological Process: anterior/posterior pattern formation; cell morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; forebrain development; in utero embryonic development; mesenchymal cell proliferation; midbrain development; middle ear morphogenesis; muscle development; negative regulation of apoptosis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of striated muscle cell differentiation; negative regulation of transcription from RNA polymerase II promoter; odontogenesis of dentine-containing teeth; palate development; positive regulation of BMP signaling pathway; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of transcription from RNA polymerase II promoter; protein stabilization; regulation of odontogenesis; transcription from RNA polymerase II promoter
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.