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Protein Page:
MSX1 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MSX1 Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity. Expressed in the developing nail bed mesenchyme. Belongs to the Msh homeobox family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 4p16.2
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: p53 binding
Biological Process: anterior/posterior pattern formation; cell morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; forebrain development; in utero embryonic development; mesenchymal cell proliferation; midbrain development; middle ear morphogenesis; muscle development; negative regulation of apoptosis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of striated muscle cell differentiation; negative regulation of transcription from RNA polymerase II promoter; odontogenesis of dentine-containing teeth; palate development; positive regulation of BMP signaling pathway; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of transcription from RNA polymerase II promoter; protein stabilization; regulation of odontogenesis; transcription from RNA polymerase II promoter
Disease: Orofacial Cleft 5; Tooth Agenesis, Selective, 1; Witkop Syndrome
Reference #:  P28360 (UniProtKB)
Alt. Names/Synonyms: homeobox 7; Homeobox protein Hox-7; Homeobox protein MSX-1; HOX7; HYD1; msh homeo box 1; msh homeobox 1; Msh homeobox 1-like protein; msh homeobox homolog 1; MSX1; STHAG1
Gene Symbols: MSX1
Molecular weight: 31,496 Da
Basal Isoelectric point: 9.89  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MSX1

Protein Structure Not Found.


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Modification Sites and Domains  
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Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K15 TSLPLGVKVEDSAFG
1 0 K133 LPEDALVKAESPEKP
0 1 R150 TPWMQSPRFSPPPAR
0 1 R157 RFSPPPARRLSPPAC
0 1 T180‑p RKPRTPFtTAQLLAL
  mouse

 
K15‑sm TSLPLGVkVEDSAFA
K133‑sm LPEDALVkAESPEKL
R150‑m2 TPWMQSPrFSPPPAr
R157‑m2 rFSPPPArRLSPPAC
T180 RKPRTPFTTAQLLAL
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