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Protein Page:
SCF (human)

SCF Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. Homodimer, non-covalently linked (Probable). Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation. Belongs to the SCF family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 12q22
Cellular Component: cytoplasm; extracellular region; filopodium; lamellipodium; plasma membrane
Molecular Function: phosphatidylinositol-4,5-bisphosphate 3-kinase activity; Ras guanyl-nucleotide exchange factor activity
Biological Process: cell proliferation; embryonic hemopoiesis; male gonad development; MAPKKK cascade; phosphoinositide-mediated signaling; positive regulation of DNA replication; regulation of phosphoinositide 3-kinase cascade; signal transduction
Disease: Deafness, Autosomal Dominant 69; Hyperpigmentation, Familial Progressive, 2; Skin/hair/eye Pigmentation, Variation In, 7
Reference #:  P21583 (UniProtKB)
Alt. Names/Synonyms: c-Kit ligand; DKFZp686F2250; familial progressive hyperpigmentation 2; FPH2; Kit ligand; Kitl; KITLG; KL-1; Mast cell growth factor; MGF; SCF; SF; SHEP7; steel factor; Stem cell factor
Gene Symbols: KITLG
Molecular weight: 30,899 Da
Basal Isoelectric point: 5.86  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  G2/M DNA Damage Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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