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Protein Page:
SCF (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SCF Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. Homodimer, non-covalently linked (Probable). Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation. Belongs to the SCF family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 12q22
Cellular Component: cytoplasm; cytoskeleton; extracellular region; extracellular space; integral to membrane; plasma membrane
Molecular Function: cytokine activity; growth factor activity; protein binding; stem cell factor receptor binding
Biological Process: activation of MAPKK activity; axon guidance; cell adhesion; cell proliferation; embryonic hemopoiesis; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; germ cell programmed cell death; innate immune response; insulin receptor signaling pathway; male gonad development; MAPKKK cascade; negative regulation of mast cell apoptosis; nerve growth factor receptor signaling pathway; neural crest cell migration; ovarian follicle development; phosphoinositide-mediated signaling; positive regulation of DNA replication; positive regulation of leukocyte migration; positive regulation of MAP kinase activity; positive regulation of melanocyte differentiation; positive regulation of myeloid leukocyte differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of Ras protein signal transduction; Ras protein signal transduction; signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway
Disease: Hyperpigmentation, Familial Progressive, 2; Skin/hair/eye Pigmentation, Variation In, 7
Reference #:  P21583 (UniProtKB)
Alt. Names/Synonyms: c-Kit ligand; DKFZp686F2250; familial progressive hyperpigmentation 2; FPH2; Kit ligand; Kitl; KITLG; KL-1; Mast cell growth factor; MGF; SCF; SF; SHEP7; steel factor; Stem cell factor
Gene Symbols: KITLG
Molecular weight: 30,899 Da
Basal Isoelectric point: 5.86  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  G2/M DNA Damage Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SCF

Protein Structure Not Found.


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Modification Sites and Domains  
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Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S147 FFRIFNRSIDAFKDF
0 1 S158 FKDFVVASETSDCVV
0 1 K181‑ub DSRVSVTkPFMLPPV
0 1 K266‑ub EISMLQEkEREFQEV
  mouse

 
S147 FFSIFNRSIDAFKDF
S158 FKDFMVASDTSDCVL
K181 DSRVSVTKPFMLPPV
K266 EISMLQQKEREFQEV
  rat

 
S147‑p FFSIFNRsIDAFKDF
S158‑p FKDFMVAsDTSDCVL
K181 DSRVSVTKPFMLPPV
K266 EISMLQQKEREFQEV
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