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Protein Page:
NPY (human)

Overview
NPY NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. Belongs to the NPY family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide; Hormone
Chromosomal Location of Human Ortholog: 7p15.1
Cellular Component: cell; extracellular region; extracellular space; Golgi apparatus
Molecular Function: calcium channel regulator activity; G-protein coupled receptor activity; G-protein-coupled receptor binding; neuropeptide hormone activity; receptor binding
Biological Process: adult feeding behavior; antibacterial humoral response; antifungal humoral response; behavior; blood circulation; calcium ion transport; cell motility; cell proliferation; central nervous system neuron development; cerebral cortex development; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; digestion; feeding behavior; G-protein signaling, coupled to cyclic nucleotide second messenger; innate immune response; neurite development; neuropeptide signaling pathway; positive regulation of appetite; regulation of appetite; regulation of blood pressure; response to yeast; synaptic transmission
Reference #:  P01303 (UniProtKB)
Alt. Names/Synonyms: C-flanking peptide of NPY; CPON; Neuropeptide tyrosine; Neuropeptide Y; NPY; PYY4
Gene Symbols: NPY
Molecular weight: 10,851 Da
Basal Isoelectric point: 6.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NPY

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 Y48‑p PAEDMARyysALRHy
0 35 Y49‑p AEDMARyysALRHyI
0 1 S50‑p EDMARyysALRHyIN
0 18 Y55‑p yysALRHyINLITRQ
0 1 S75‑p SSPETLIsDLLMREs
0 7 S82‑p sDLLMREstENVPRT
0 3 T83‑p DLLMREstENVPRTR
  mouse

 
Y48 PAEDMARYYSALRHY
Y49 AEDMARYYSALRHYI
S50 EDMARYYSALRHYIN
Y55 YYSALRHYINLITRQ
S75 SSPETLISDLLMKEs
S82‑p SDLLMKEstENAPRT
T83‑p DLLMKEstENAPRTR
  rat

 
Y49 PAEDMARYYSALRHY
Y50 AEDMARYYSALRHYI
S51 EDMARYYSALRHYIN
Y56 YYSALRHYINLITRQ
S76 SSPETLISDLLMREs
S83‑p SDLLMREsTENAPRT
T84 DLLMREsTENAPRTR
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