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Protein Page:
MBD3 (human)

MBD3 methyl-CpG binding (MBD) proteins appear to bind differentially methylated domains (DMDs) of DNA, to recruit repression complexes, and to silence the locus. The methyl CpG binding domain of human MBD3 may not directly bind mCpG but does interact with the NuRD/Mi2 components HDAC1 and MTA2. Plays a role in histone deacetylation and nucleosome remodeling. Increased levels have been reported in lung cancer and glioblastomas and may be a therapeutic target. Note: This description may include information from UniProtKB.
Protein type: Gene silencing; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: nuclear chromatin; nucleoplasm; protein complex
Molecular Function: DNA binding; histone deacetylase activity; methyl-CpG binding; nucleosomal DNA binding; protein binding
Biological Process: ATP-dependent chromatin remodeling; methylation-dependent chromatin silencing; negative regulation of transcription from RNA polymerase II promoter
Reference #:  O95983 (UniProtKB)
Alt. Names/Synonyms: MBD3; methyl-CpG binding domain protein 3; Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3
Gene Symbols: MBD3
Molecular weight: 32,844 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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