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Protein Page:
RRAGB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RRAGB Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. Involved in the RCC1/Ran-GTPase pathway. The short isoform binds GTP. Interacts with RRAGC and RRAGD. Belongs to the GTR/RAG GTP-binding protein family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: Xp11.21
Cellular Component: cytoplasm; cytosol; Golgi apparatus; intracellular membrane-bound organelle; lysosomal membrane; lysosome; nucleus
Molecular Function: GTP binding; GTPase activity; guanyl ribonucleotide binding; protein binding
Biological Process: cell cycle arrest; cellular response to amino acid starvation; macroautophagy; positive regulation of TOR signaling pathway; regulation of autophagy; regulation of TOR signaling pathway
Reference #:  Q5VZM2 (UniProtKB)
Alt. Names/Synonyms: bA465E19.1; GTP-binding protein ragB; Rag B; RagB; Ras-related GTP binding B; Ras-related GTP-binding protein B; RRAGB
Gene Symbols: RRAGB
Molecular weight: 43,250 Da
Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states
CST Pathways:  mTOR Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RRAGB

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S4‑p ____MEEsDsEKTTE
0 1 S6‑p __MEEsDsEKTTEKE
0 1 Y278‑p TFLVISHyQCKEQRD
0 1 K281 VISHyQCKEQRDAHR
0 1 K297‑ac EKISNIIkQFkLSCS
0 1 K300‑ac SNIIkQFkLSCSkLA
0 1 K305‑ac QFkLSCSkLAASFQS
0 2 K305‑ub QFkLSCSkLAASFQS
  mouse

 
S4 ____MEESDSEKKTE
S6 __MEESDSEKKTEKE
Y278 TFLVISHYQCkEQRD
K281‑ub VISHYQCkEQRDAHR
K297 EKISNIIKQFKLSCS
K300 SNIIKQFKLSCSkLA
K305 QFKLSCSKLAASFQS
K305‑ub QFKLSCSkLAASFQS
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