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Protein Page:
SMARCA1 (human)

Overview
SMARCA1 Energy-transducing component of NURF (nucleosome- remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes. Both complexes facilitate the perturbation of chromatin structure in an ATP-dependent manner. Potentiates neurite outgrowth. May be involved in brain development by regulating En-1 and En-2 expression. May be involved in the development of luteal cells. Part of the nucleosome-remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Part of the CECR2-containing-remodeling factor (CERF) complex which contains CECR2 and SMARCA1. Interacts with PRLR. Belongs to the SNF2/RAD54 helicase family. ISWI subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; EC 3.6.1.-; EC 3.6.4.-; Helicase; Transcription regulation
Chromosomal Location of Human Ortholog: Xq25
Cellular Component: nucleus
Molecular Function: DNA-dependent ATPase activity; protein binding
Biological Process: ATP-dependent chromatin remodeling; brain development; chromatin remodeling; neuron differentiation; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent
Reference #:  P28370 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent helicase SMARCA1; DKFZp686D1623; FLJ41547; ISWI; Nucleosome-remodeling factor subunit SNF2L; NURF140; Probable global transcription activator SNF2L1; SMARCA1; SMCA1; SNF2-like 1; SNF2L; SNF2L1; SNF2LB; sucrose nonfermenting 2-like protein 1; SWI; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1; SWI2
Gene Symbols: SMARCA1
Molecular weight: 122,605 Da
Basal Isoelectric point: 8.27  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SMARCA1

Protein Structure Not Found.


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