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Protein Page:
CA12 (human)

CA12 Reversible hydration of carbon dioxide. Homodimer. Highly expressed in colon, kidney, prostate, intestine and activated lymphocytes. Expressed at much higher levels in the renal cell cancers than in surrounding normal kidney tissue. Moderately expressed in pancreas, ovary and testis. Inhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA), benzenesulfonamide and derivatives (4-carboxyethylbenzene-sulfonamide, 4- carboxyethylbenzene-sulfonamide ethyl ester, 4-(acetyl-2- aminoethyl)benzene-sulfonamide, 4-aminoethylbenzene-sulfonamide) and Foscarnet (phosphonoformate trisodium salt). Belongs to the alpha-carbonic anhydrase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Energy Metabolism - nitrogen; Lyase; Membrane protein, integral
Chromosomal Location of Human Ortholog: 15q22
Cellular Component: plasma membrane
Molecular Function: carbonate dehydratase activity
Biological Process: bicarbonate transport; chloride ion homeostasis
Disease: Hyperchlorhidrosis, Isolated
Reference #:  O43570 (UniProtKB)
Alt. Names/Synonyms: CA-XII; CA12; CAH12; Carbonate dehydratase XII; Carbonic anhydrase 12; Carbonic anhydrase XII; CAXII; FLJ20151; HsT18816; Tumor antigen HOM-RCC-3.1.3
Gene Symbols: CA12
Molecular weight: 39,451 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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