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Protein Page:
EphB6 (human)

Overview
EphB6 Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Eph family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 7q33-q35
Cellular Component: cytosol; extracellular region; plasma membrane
Molecular Function: receptor activity
Biological Process: ephrin receptor signaling pathway
Reference #:  O15197 (UniProtKB)
Alt. Names/Synonyms: EPH receptor B6; EPHB6; Ephrin type-B receptor 6; HEP; MGC129910; MGC129911; Tyrosine-protein kinase-defective receptor EPH-6
Gene Symbols: EPHB6
Molecular weight: 110,700 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

EphB6

Protein Structure Not Found.


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