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Protein Page:
RECK (human)

Overview
RECK Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression. Interacts with MMP-9. Expressed in various tissues and untransformed cells. It is undetectable in tumor-derived cell lines and oncogenically transformed cells. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, GPI anchor; Tumor suppressor
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component: membrane; plasma membrane
Molecular Function: endopeptidase inhibitor activity; metalloendopeptidase inhibitor activity; protein binding; serine-type endopeptidase inhibitor activity
Biological Process: blood vessel maturation; embryo implantation; embryonic forelimb morphogenesis; extracellular matrix organization and biogenesis; negative regulation of cell migration
Reference #:  O95980 (UniProtKB)
Alt. Names/Synonyms: hRECK; membrane-anchored glycoprotein (metastasis and invasion); RECK; Reversion-inducing cysteine-rich protein with Kazal motifs; reversion-inducing-cysteine-rich protein with kazal motifs; ST15; suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs); suppression of tumorigenicity 5 (reversion-inducing-cysteine-rich protein with kazal motifs); Suppressor of tumorigenicity 15 protein
Gene Symbols: RECK
Molecular weight: 106,457 Da
Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RECK

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 N83 ETMVEIWNCMNSSLP
0 1 Y154‑p MGSVCCSyAGHHTNC
0 1 Y164‑p HHTNCREyCQAIFRT
0 1 S294‑p GAKLHCCsKANtstC
0 1 T298‑p HCCsKANtstCRELC
0 1 S299‑p CCsKANtstCRELCT
0 1 T300‑p CsKANtstCRELCTK
0 1 T843‑p FDKEKLDtIAKVtNK
0 1 T848‑p LDtIAKVtNKKPITV
0 1 T969‑p LALHLLWtyN_____
0 1 Y970‑p ALHLLWtyN______
  mouse

 
S83‑p ETMVEIWsCMNSSLP
Y154 MGSVCCSYAGHHTNC
F164 HHTNCREFCQAIFRT
S294 GAKLHCCSKANTSTC
T298 HCCSKANTSTCRELC
S299 CCSKANTSTCRELCT
T300 CSKANTSTCRELCTK
T843 FDKEKLDTIAKVTSK
T848 LDTIAKVTSKKPITV
T969 LTVHLLWTRP_____
R970 TVHLLWTRP______
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