Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. Belongs to the methyltransferase superfamily. LCMT family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - histidine; Amino Acid Metabolism - tyrosine; EC 18.104.22.168; Lipid Metabolism - androgen and estrogen; Methyltransferase; Other Amino Acids Metabolism - selenoamino acid
Cellular Component: cytosol
Molecular Function: C-terminal protein carboxyl methyltransferase activity; protein methyltransferase activity; protein-leucine O-methyltransferase activity
Biological Process: C-terminal protein amino acid methylation; negative regulation of protein complex assembly; protein amino acid methylation; regulation of apoptosis