Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
TIMP3 (human)

Overview
TIMP3 Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. Interacts with EFEMP1. Belongs to the protease inhibitor I35 (TIMP) family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 22q12.3
Cellular Component: basement membrane; cytoplasm; extracellular matrix; extracellular space; nucleus; proteinaceous extracellular matrix
Molecular Function: metal ion binding; metalloendopeptidase inhibitor activity; protease binding; protein binding
Biological Process: aging; central nervous system development; negative regulation of membrane protein ectodomain proteolysis; negative regulation of metalloenzyme activity; response to estrogen stimulus; response to folic acid; response to mechanical stimulus; response to organic substance; tissue regeneration; visual perception
Disease: Fundus Dystrophy, Pseudoinflammatory, Of Sorsby
Reference #:  P35625 (UniProtKB)
Alt. Names/Synonyms: HSMRK222; K222; K222TA2; Metalloproteinase inhibitor 3; MIG-5 protein; Protein MIG-5; SFD; TIMP metallopeptidase inhibitor 3; TIMP-3; TIMP3; Tissue inhibitor of metalloproteinases 3
Gene Symbols: TIMP3
Molecular weight: 24,145 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TIMP3

Protein Structure Not Found.


STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB


Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y100‑p LKLEVNKyQYLLTGR
0 1 Y177‑p SNFGYPGyQSKHyAC
0 1 Y182‑p PGyQSKHyACIRQKG
0 2 Y195‑p KGGYCSWyRGWAPPD
  mouse

 
Y100 LKLEVNKYQYLLTGR
Y177 SNFGYPGYQSKHYAC
Y182 PGYQSKHYACIRQKG
Y195 KGGYCSWYRGWAPPD
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.