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Protein Page:
TGFB3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TGFB3 Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Secreted, signal peptide; Ligand, receptor tyrosine kinase; Motility/polarity/chemotaxis; Secreted
Chromosomal Location of Human Ortholog: 14q24
Cellular Component: cell soma; cell surface; extracellular matrix; extracellular region; extracellular space; nucleus; plasma membrane; proteinaceous extracellular matrix; T-tubule
Molecular Function: cytokine activity; growth factor activity; identical protein binding; protein binding; protein heterodimerization activity; punt binding; transforming growth factor beta binding
Biological Process: activation of MAPK activity; aging; alveolus development; blood coagulation; cell development; cell growth; embryonic neurocranium morphogenesis; extracellular matrix organization and biogenesis; female pregnancy; gut development; in utero embryonic development; inner ear development; intercellular junction assembly and maintenance; mammary gland development; negative regulation of cell proliferation; negative regulation of DNA replication; negative regulation of neuron apoptosis; negative regulation of transforming growth factor beta receptor signaling pathway; odontogenesis; palate development; platelet activation; platelet degranulation; positive regulation of apoptosis; positive regulation of bone mineralization; positive regulation of cell division; positive regulation of collagen biosynthetic process; positive regulation of DNA replication; positive regulation of filopodium formation; positive regulation of protein secretion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of cell proliferation; regulation of MAPKKK cascade; response to estrogen stimulus; response to hypoxia; response to progesterone stimulus; salivary gland morphogenesis; SMAD protein nuclear translocation; transforming growth factor beta receptor signaling pathway; uterine wall breakdown
Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 1; Rienhoff Syndrome
Reference #:  P10600 (UniProtKB)
Alt. Names/Synonyms: ARVD; FLJ16571; TGF-beta-3; TGF-beta3; TGFB3; Transforming growth factor beta-3; transforming growth factor, beta 3
Gene Symbols: TGFB3
Molecular weight: 47,328 Da
Basal Isoelectric point: 8.31  Predict pI for various phosphorylation states
CST Pathways:  Regulation of P38 MAPKs  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TGFB3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T54 ILSKLRLTSPPEPTV
0 1 S55 LSKLRLTSPPEPTVM
0 1 Y67 TVMTHVPYQVLALYN
0 1 K162‑m3 RVPNPSSkRNEQRIE
0 2 Y185‑p EHIAKQRyIGGKNLP
0 1 N290 IPPHRLDNPGQGGQR
0 1 K299‑ac GQGGQRKkRALDTNY
  mouse

 
T52‑p ILSKLRLtsPPEPSV
S53‑p LSKLRLtsPPEPSVM
Y65‑p SVMTHVPyQVLALYN
K160 RVPNPSSKRTEQRIE
Y183 EHIAKQRYIGGKNLP
S288‑p IPPHRLDsPGQGSQR
K297 GQGSQRKKRALDTNY
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