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Protein Page:
TGFB2 (human)

TGFB2 TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth. Homodimer; disulfide-linked. Heterodimers with TGFB1 and with TGFB3 have been found in bone. Interacts with the serine proteases, HTRA1 and HTRA3. Interacts with ASPN. Belongs to the TGF-beta family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Secreted; Cell development/differentiation; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1q41
Cellular Component: axon; cell soma; endosome; extracellular matrix; extracellular region; extracellular space
Molecular Function: beta-amyloid binding; cytokine activity; growth factor activity; protein binding; protein heterodimerization activity; protein homodimerization activity; punt binding; receptor binding; receptor signaling protein serine/threonine kinase activity; transforming growth factor beta receptor binding
Biological Process: activation of protein kinase activity; angiogenesis; axon guidance; blood vessel remodeling; cardiac muscle cell proliferation; cardioblast differentiation; cartilage condensation; catagen; cell cycle arrest; cell death; cell growth; cell migration; cell morphogenesis; cell proliferation; cell-cell signaling; collagen fibril organization; dopamine biosynthetic process; embryonic development; embryonic gut development; epithelial to mesenchymal transition; eye development; generation of neurons; glial cell migration; hair follicle development; hair follicle morphogenesis; heart development; heart morphogenesis; hemopoiesis; intercellular junction assembly and maintenance; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of immune response; negative regulation of Ras protein signal transduction; neuron development; neuron fate commitment; neutrophil chemotaxis; odontogenesis; platelet degranulation; positive regulation of cardioblast differentiation; positive regulation of catagen; positive regulation of cell adhesion mediated by integrin; positive regulation of cell cycle; positive regulation of cell division; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of heart contraction; positive regulation of immune response; positive regulation of integrin biosynthetic process; positive regulation of neuron apoptosis; positive regulation of ossification; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein secretion; positive regulation of stress-activated MAPK cascade; protein amino acid phosphorylation; regulation of actin cytoskeleton organization and biogenesis; regulation of transforming growth factor-beta2 production; response to drug; response to hypoxia; response to progesterone stimulus; response to wounding; salivary gland morphogenesis; SMAD protein nuclear translocation; somatic stem cell division; transforming growth factor beta receptor signaling pathway; uterine wall breakdown; wound healing
Disease: Loeys-dietz Syndrome 4
Reference #:  P61812 (UniProtKB)
Alt. Names/Synonyms: BSC-1 cell growth inhibitor; Cetermin; G-TSF; Glioblastoma-derived T-cell suppressor factor; MGC116892; Polyergin; TGF-beta-2; TGF-beta2; TGFB2; Transforming growth factor beta-2; transforming growth factor, beta 2
Gene Symbols: TGFB2
Molecular weight: 47,748 Da
Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states
CST Pathways:  Regulation of P38 MAPKs  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

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LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.



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