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Protein Page:
AP-2 beta (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AP-2 beta Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. Belongs to the AP-2 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 6p12
Cellular Component: nucleus
Molecular Function: caspase inhibitor activity; DNA binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; transcription coactivator activity; transcription corepressor activity; transcription factor activity
Biological Process: calcium ion homeostasis; fat cell differentiation; forelimb morphogenesis; glucose homeostasis; glucose metabolic process; hindlimb morphogenesis; kidney development; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; phosphate ion homeostasis; positive regulation of cell proliferation; positive regulation of neuron apoptosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; potassium ion homeostasis; regulation of BMP signaling pathway; regulation of cell differentiation; regulation of insulin secretion; regulation of transcription, DNA-dependent; renal water homeostasis; sodium ion homeostasis; sympathetic nervous system development
Disease: Char Syndrome
Reference #:  Q92481 (UniProtKB)
Alt. Names/Synonyms: activating enhancer binding protein 2 beta; Activating enhancer-binding protein 2-beta; AP-2B; AP2-B; AP2-beta; AP2B; MGC21381; TFAP2B; transcription factor AP-2 beta (activating enhancer binding protein 2 beta); Transcription factor AP-2-beta
Gene Symbols: TFAP2B
Molecular weight: 50,474 Da
Basal Isoelectric point: 8.41  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AP-2 beta

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S3‑p _____MHsPPRDQAA
0 1 K15‑ub QAAIMLWkLVENVKY
0 1 S120‑p EVGSEAGsLLPQPRA
0 5 S258‑p GEVQRRLsPPECLNA
0 1 R282 AKSKNGGRSLRERLE
  AP-2 beta iso2  
S3 _____MHSPPRDQAA
K15 QAAIMLWKLVENVKY
S129 EVGSEAGSLLPQPRA
S267 GEVQRRLSPPECLNA
R291 AKSKNGGRSLRERLE
  mouse

 
S3‑p _____MHsPPRDQAA
K15 QAAIMLWKLVENVKY
S120 EVGSEAGSLLPQPRA
S258‑p GEVQRRLsPPECLNA
R282‑m1 AKSKNGGrSLRERLE
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