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Protein Page:
PLA2G1B (human)

Overview
PLA2G1B PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Belongs to the phospholipase A2 family. Note: This description may include information from UniProtKB.
Protein type: Lipid Metabolism - glycerophospholipid; Phospholipase; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - linoleic acid; Secreted; Secreted, signal peptide; DNA replication; Lipid Metabolism - ether lipid; Lipid Metabolism - arachidonic acid; EC 3.1.1.4
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component: cell surface; extracellular region; extracellular space; secretory granule
Molecular Function: bile acid binding; calcium ion binding; calcium-dependent phospholipase A2 activity; phospholipase A2 activity; receptor binding
Biological Process: actin filament organization; activation of MAPK activity; activation of NF-kappaB transcription factor; activation of phospholipase A2; antibacterial humoral response; arachidonic acid secretion; cellular response to insulin stimulus; defense response to Gram-positive bacterium; fatty acid biosynthetic process; glucose transport; glycerophospholipid biosynthetic process; innate immune response in mucosa; interleukin-8 production; leukotriene biosynthetic process; multicellular organismal lipid catabolic process; neutrophil chemotaxis; neutrophil mediated immunity; phosphatidic acid biosynthetic process; phosphatidylcholine metabolic process; phospholipid metabolic process; positive regulation of DNA replication; positive regulation of fibroblast proliferation; positive regulation of immune response; positive regulation of protein secretion; positive regulation of transcription from RNA polymerase II promoter; signal transduction
Reference #:  P04054 (UniProtKB)
Alt. Names/Synonyms: Group IB phospholipase A2; MGC119834; MGC119835; PA21B; Phosphatidylcholine 2-acylhydrolase 1B; Phospholipase A2; phospholipase A2, group IB (pancreas); PLA2; PLA2A; PLA2G1B; PPLA2
Gene Symbols: PLA2G1B
Molecular weight: 16,360 Da
Basal Isoelectric point: 8.16  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PLA2G1B

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y95‑p DNPYTHTySySCSGS
0 1 Y97‑p PYTHTySySCSGSAI
  mouse

 
Y95 DNPYTNTYSYSCSGS
Y97 PYTNTYSYSCSGSEI
  rat

 
Y95 DNPYTNTYSYKCSGN
Y97 PYTNTYSYKCSGNVI
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