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Protein Page:
PLA2G1B (human)

PLA2G1B PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Belongs to the phospholipase A2 family. Note: This description may include information from UniProtKB.
Protein type: Lipid Metabolism - arachidonic acid; Lipid Metabolism - alpha-linolenic acid; EC; Phospholipase; Lipid Metabolism - linoleic acid; Secreted; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - ether lipid; DNA replication; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component: cell surface; extracellular region; extracellular space; secretory granule
Molecular Function: bile acid binding; calcium ion binding; calcium-dependent phospholipase A2 activity; phospholipase A2 activity; receptor binding
Biological Process: actin filament organization; activation of MAPK activity; activation of NF-kappaB transcription factor; activation of phospholipase A2; antibacterial humoral response; arachidonic acid secretion; cellular response to insulin stimulus; defense response to Gram-positive bacterium; fatty acid biosynthetic process; glucose transport; innate immune response in mucosa; interleukin-8 production; leukotriene biosynthetic process; multicellular organismal lipid catabolic process; neutrophil chemotaxis; neutrophil mediated immunity; phosphatidic acid biosynthetic process; phosphatidylcholine metabolic process; positive regulation of DNA replication; positive regulation of fibroblast proliferation; positive regulation of immune response; positive regulation of protein secretion; positive regulation of transcription from RNA polymerase II promoter; signal transduction
Reference #:  P04054 (UniProtKB)
Gene Symbols: PLA2G1B
Molecular weight: 16,360 Da
Basal Isoelectric point: 8.16  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.
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