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Protein Page:
PAX5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PAX5 May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene. Interacts with DAXX. Binds DNA as a monomer. Binds TLE4. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein
Chromosomal Location of Human Ortholog: 9p13
Molecular Function: protein binding
Biological Process: humoral immune response; multicellular organismal development; organ morphogenesis
Disease: Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Reference #:  Q02548 (UniProtKB)
Alt. Names/Synonyms: B cell specific activator protein; B-cell lineage specific activator; B-cell-specific transcription factor; BSAP; paired box 5; paired box homeotic gene 5; Paired box protein Pax-5; PAX5; transcription factor PAX 5
Gene Symbols: PAX5
Molecular weight: 42,149 Da
Basal Isoelectric point: 9.08  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PAX5

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T9‑p DLEKNYPtPRTSRtG
0 1 T15‑p PtPRTSRtGHGGVNQ
0 1 Y102‑p VVEKIAEyKRQNPTM
0 1 S168‑p TGSVTQVsSVSTDSA
0 1 Y179‑p TDSAGSSysISGILG
0 1 S180‑p DSAGSSysISGILGI
0 1 S206‑p RDEGIQEsPVPNGHS
0 1 R225 DFLRKQMRGDLFTQQ
0 1 R243 VLDRVFERQHYSDIF
0 1 S298‑p SSVPGPQsyPIVTGR
0 1 Y299‑p SVPGPQsyPIVTGRD
  mouse

 
T9 DLEKNYPTPRTIRTG
T15 PTPRTIRTGHGGVNQ
Y102 VVEKIAEYKRQNPTM
S168 TGSVTQVSSVSTDSA
Y179 TDSAGSSYSISGILG
S180 DSAGSSYSISGILGI
S206 RDEGIQESPVPNGHS
R225‑m1 DFLRKQMrGDLFTQQ
R243‑m1 VLDRVFErQHYSDIF
S298 SSVPGPQSYPIVTGR
Y299 SVPGPQSYPIVTGRD
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