This tyrosine kinase receptor for fibrillar collagen mediates fibroblast migration and proliferation. Contributes to cutaneous wound healing. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 188.8.131.52; Kinase, protein; Protein kinase, tyrosine (receptor); Membrane protein, integral; Protein kinase, TK; TK group; DDR family
Cellular Component: focal adhesion; integral to plasma membrane; plasma membrane
Molecular Function: ATP binding; collagen binding; protein binding; transmembrane receptor protein tyrosine kinase activity
Biological Process: biomineral formation; cell adhesion; collagen fibril organization; extracellular matrix organization and biogenesis; ossification; peptidyl-tyrosine phosphorylation; positive regulation of fibroblast proliferation; positive regulation of osteoblast differentiation; positive regulation of protein kinase activity; positive regulation of transcription factor activity; protein amino acid autophosphorylation; regulation of bone mineralization; signal transduction
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.