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Protein Page:
CYP19A1 (human)

Overview
CYP19A1 Catalyzes the formation of aromatic C18 estrogens from C19 androgens. Belongs to the cytochrome P450 family. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; EC 1.14.14.14; Lipid Metabolism - androgen and estrogen
Chromosomal Location of Human Ortholog: 15q21.1
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; membrane
Molecular Function: electron carrier activity; heme binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; oxygen binding
Biological Process: androgen metabolic process; estrogen biosynthetic process; negative regulation of chronic inflammatory response; steroid biosynthetic process; steroid metabolic process; sterol metabolic process; xenobiotic metabolic process
Disease: Aromatase Deficiency; Aromatase Excess Syndrome
Reference #:  P11511 (UniProtKB)
Alt. Names/Synonyms: ARO; ARO1; Aromatase; CP19A; CPV1; CYAR; CYP19; CYP19A1; CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; cytochrome P450, family 19, subfamily A, polypeptide 1; cytochrome P450, subfamily XIX (aromatization of androgens); Estrogen synthase; estrogen synthetase; flavoprotein-linked monooxygenase; MGC104309; microsomal monooxygenase; P-450AROM
Gene Symbols: CYP19A1
Molecular weight: 57,883 Da
Basal Isoelectric point: 7.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CYP19A1

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: Y361‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y112‑p HIMKHNHySSRFGSK
1 0 S118 HySSRFGSKLGLQCI
0 1 T162‑p PGLVRMVtVCAESLK
0 1 T201‑p VMLDTSNtLFLRIPL
0 1 Y220‑p IVVKIQGyFDAWQAL
0 1 Y241‑p FFKISWLyKKYEKSV
1 0 Y361‑p KVMENFIyESMRYQP
0 3 T392‑p GYPVKKGtNIILNIG
0 1 Y441‑p PRGCAGKyIAMVMMK
0 1 T484‑p LSLHPDEtKNMLEMI
0 1 S497‑p MIFTPRNsDRCLEH_
  mouse

 
Y112 HVMKHSHYISRFGsK
S118‑p HYISRFGsKRGLQCI
E162 PGLVRMVEVCVESIK
M201 IMLDTSNMLFLGIPL
Y220 IVKKIQGYFNAWQAL
Y241 FFKISWLYRKYERSV
N361 KVVENFINESMRYQP
T392‑p GYPVKKGtNIILNIG
Y441 PRGCAGKYIAMVMMK
D484 LSLHPNEDRHLVEII
S497 IIFSPRNSDKYLQQ_
  rat

 
Y112 HVMKHSNYISRFGSK
S118 NYISRFGSKRGLQCI
E162 PGLIRMVEVCVESIK
T201 IMLDTSNTLFLGIPL
Y220 IVKKIQGYFNAWQAL
Y241 FFKISWLYRKYERSV
N361 KVVENFINESLRYQP
T392 GYPVKKGTNIILNIG
Y441 PRSCAGKYIAMVMMK
D484 LSLHLDEDSPIVEII
N497 IIFRHIFNTPFLQCL
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