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Protein Page:
CCK4 (human)

Overview
CCK4 Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: CCK4 family; EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component: focal adhesion; intercellular junction
Molecular Function: protein binding
Biological Process: actin cytoskeleton reorganization; cell migration; signal transduction; Wnt receptor signaling pathway through beta-catenin
Reference #:  Q13308 (UniProtKB)
Alt. Names/Synonyms: CCK-4; CCK4; Colon carcinoma kinase 4; colon carcinoma kinase-4; Protein-tyrosine kinase 7; PTK7; PTK7 protein tyrosine kinase 7; Tyrosine-protein kinase-like 7
Gene Symbols: PTK7
Molecular weight: 118,392 Da
Basal Isoelectric point: 6.67  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CCK4

Protein Structure Not Found.


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