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Protein Page:
TNK1 (human)

Overview
TNK1 Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. Interacts with the SH3 domain of PLCG1 via its Pro-rich domain. Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain. Belongs to the protein kinase superfamily. Tyr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Ack family; EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: cytoplasm; extrinsic to internal side of plasma membrane; membrane
Molecular Function: ATP binding; protein binding; protein-tyrosine kinase activity; receptor binding; signal transducer activity
Biological Process: cell differentiation; innate immune response; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q13470 (UniProtKB)
Alt. Names/Synonyms: CD38 negative kinase 1; MGC46193; Non-receptor tyrosine-protein kinase TNK1; TNK1; tyrosine kinase, non-receptor, 1
Gene Symbols: TNK1
Molecular weight: 72,468 Da
Basal Isoelectric point: 9.57  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TNK1

Protein Structure Not Found.


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