a tyrosine kinase that binds Cdc42 in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. May be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42 and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Amplification in primary tumors correlates with metastatic potential . Two differentially spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, tyrosine (non-receptor); Kinase, protein; EC 220.127.116.11; Protein kinase, TK; EC 18.104.22.168; TK group; Ack family
Cellular Component: adherens junction; axon; cell soma; clathrin-coated vesicle; coated pit; cytoplasm; cytoplasmic vesicle membrane; dendrite; endosome; extrinsic to internal side of plasma membrane; growth cone; membrane; nucleus; plasma membrane
Molecular Function: ATP binding; epidermal growth factor receptor binding; GTPase inhibitor activity; identical protein binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein-tyrosine kinase activity; WW domain binding
Biological Process: cell differentiation; cell migration; cell surface receptor linked signal transduction; endocytosis; innate immune response; phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; regulation of cell proliferation; small GTPase mediated signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.