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Protein Page:
UBE2T (human)

Overview
UBE2T Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Belongs to the ubiquitin-conjugating enzyme family. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: chromatin binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity
Biological Process: DNA repair; protein autoubiquitination; protein monoubiquitination; response to DNA damage stimulus
Disease: Fanconi Anemia, Complementation Group T
Reference #:  Q9NPD8 (UniProtKB)
Alt. Names/Synonyms: Cell proliferation-inducing gene 50 protein; HSPC150; HSPC150 protein similar to ubiquitin-conjugating enzyme; PIG50; UBE2T; Ubiquitin carrier protein T; ubiquitin conjugating enzyme; Ubiquitin-conjugating enzyme E2 T; ubiquitin-conjugating enzyme E2T (putative); Ubiquitin-protein ligase T
Gene Symbols: UBE2T
Molecular weight: 22,521 Da
Basal Isoelectric point: 7.78  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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UBE2T

Protein Structure Not Found.
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