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Protein Page:
MCM4 (human)

Overview
MCM4 a mini-chromosome maintenance protein, essential for the initiation of eukaryotic genome replication. The MCM hexameric protein complex is a key component of the pre-replication complex. The complex consisting of this protein and MCM2, 6 and 7 possesses DNA helicase activity. Phosphorylation by CDC2 reduces the DNA helicase activity and chromatin binding of the complex. Note: This description may include information from UniProtKB.
Protein type: DNA replication; EC 3.6.4.12
Chromosomal Location of Human Ortholog: 8q11.2
Cellular Component: MCM complex; membrane; nuclear chromosome, telomeric region; nucleoplasm
Molecular Function: ATP-dependent DNA helicase activity; protein binding
Biological Process: DNA replication; G1/S transition of mitotic cell cycle
Disease: Natural Killer Cell And Glucocorticoid Deficiency With Dna Repair Defect
Reference #:  P33991 (UniProtKB)
Alt. Names/Synonyms: CDC21; CDC21 homolog; CDC54; DNA replication licensing factor MCM4; hCdc21; homolog of S. pombe cell devision cycle 21; MCM4; MCM4 minichromosome maintenance deficient 4; MGC33310; minichromosome maintenance complex component 4; minichromosome maintenance deficient 4; P1-CDC21
Gene Symbols: MCM4
Molecular weight: 96,558 Da
Basal Isoelectric point: 6.28  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MCM4

Protein Structure Not Found.


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