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Protein Page:
DLST (human)

DLST The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). Forms a 24-polypeptide structural core with octahedral symmetry. Belongs to the 2-oxoacid dehydrogenase family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - lysine degradation; Carbohydrate Metabolism - citrate (TCA) cycle; EC; Mitochondrial; Transferase
Chromosomal Location of Human Ortholog: 14q24.3
Cellular Component: membrane; mitochondrial matrix; nucleus
Biological Process: generation of precursor metabolites and energy; glyoxylate metabolic process; lysine catabolic process; tricarboxylic acid cycle
Reference #:  P36957 (UniProtKB)
Alt. Names/Synonyms: 2-oxoglutarate dehydrogenase complex component E2; dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex); Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; DLST; DLTS; E2K; ODO2; OGDC-E2
Gene Symbols: DLST
Molecular weight: 48,755 Da
Basal Isoelectric point: 9.1  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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