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Protein Page:
CCR2 (human)

Overview
CCR2 a seven transmembrane protein closely related to CCR1. Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. Transduces a signal by increasing the intracellular calcium ions level. Alternative co receptor with CD4 for HIV-1 infection. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: cell soma; cell surface; cytoplasm; cytosol; dendrite; endosome; integral to membrane; integral to plasma membrane; perikaryon; perinuclear region of cytoplasm; plasma membrane
Molecular Function: C-C chemokine receptor activity; CCR2 chemokine receptor binding; chemokine receptor activity; protein homodimerization activity; protein kinase binding
Biological Process: aging; blood vessel remodeling; cellular calcium ion homeostasis; cellular defense response; cellular homeostasis; chemotaxis; cytokine and chemokine mediated signaling pathway; defense response to bacterium; dendritic cell chemotaxis; elevation of cytosolic calcium ion concentration; fat cell differentiation; forebrain development; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; inflammatory response to antigenic stimulus; innate immune response; JAK-STAT cascade; negative regulation of adenylate cyclase activity; negative regulation of angiogenesis; negative regulation of axon extension; negative regulation of cell migration; negative regulation of eosinophil degranulation; negative regulation of T-helper 2 type immune response; positive regulation of alpha-beta T cell proliferation; positive regulation of apoptosis by virus; positive regulation of fever; positive regulation of inflammatory response; positive regulation of interferon-gamma production; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-2 production; positive regulation of interleukin-6 production; positive regulation of neuron differentiation; positive regulation of T cell activation; positive regulation of T-helper 1 type immune response; positive regulation of tumor necrosis factor biosynthetic process; response to ionizing radiation; response to lipopolysaccharide; response to wounding
Reference #:  P41597 (UniProtKB)
Alt. Names/Synonyms: C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; CCR2A; CCR2B; CD192; chemokine (C-C motif) receptor 2; CKR2; CKR2A; CKR2B; CMKBR2; FLJ78302; MCP-1 receptor; MCP-1-R; MGC103828; MGC111760; MGC168006; Monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor
Gene Symbols: CCR2
Molecular weight: 41,915 Da
Basal Isoelectric point: 9.24  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CCR2

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: Y139‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 Y139‑p ILLTIDRyLAIVHAV
0 1 S367 IGRAPEASLQDKEGA
  mouse

 
Y152 ILLTIDRYLAIVHAV
S370‑p STGEQEVsVGL____
  rat

 
Y152 ILLTIDRYLAIVHAV
S370 STGEQEVSVGL____
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